Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Corydalis saxicola Alkaloids Attenuate Cisplatin-Induced Neuropathic Pain by Reducing Loss of IENF and Blocking TRPV1 Activation.
TL;DR: It has been verified that cisplatin-induced peripheral neuropathy is related to intraepidermal nerve fibers loss and activation of inflammation downstream, and CSBTA could normalize the overexpression levels of p-p38 and Transient receptor potential vanilloid receptor (TRPV1) induced by cis Platin.
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New Insights into Potential Prevention and Management Options for Chemotherapy-Induced Peripheral Neuropathy.
TL;DR: New insights into mechanisms of action from chemotherapy agents may facilitate the development of novel preventative and treatment options, thereby enabling medical staff to better support patients by reducing this debilitating side effect.
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Treatment for paraneoplastic neuropathies
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Genetic risk factors for VIPN in childhood acute lymphoblastic leukemia patients identified using whole-exome sequencing.
Rachid Abaji,Rachid Abaji,Francesco Ceppi,Swati Patel,Vincent Gagné,Chang J Xu,Jean-François Spinella,Antonella Colombini,Rosanna Parasole,Barbara Buldini,Giuseppe Basso,Valentino Conter,Giovanni Cazzaniga,Jean-Marie Leclerc,Jean-Marie Leclerc,Caroline Laverdière,Caroline Laverdière,Daniel Sinnett,Daniel Sinnett,Maja Krajinovic,Maja Krajinovic,Maja Krajinovic +21 more
TL;DR: Variants in SYNE2, MRPL47 and BAHD1 genes are putative new risk factors for VIPN in childhood acute lymphoblastic leukemia.
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Using wearables to screen motor performance deterioration because of cancer and chemotherapy-induced peripheral neuropathy (CIPN) in adults - Toward an early diagnosis of CIPN.
Mohsen Zahiri,Kevin M. Chen,He Zhou,Hung Nguyen,Biruh Workeneh,Sarvari Venkata Yellapragada,Yvonne H. Sada,Michael Schwenk,Bijan Najafi +8 more
TL;DR: These results confirmed the negative impact of CIPN on motor-performance with the largest effects on ankle stability and stride-time and VPT is a predictor of motor deterioration and may be used to determine the severity of C IPN symptom.
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