Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.
Marta Seretny,Gillian L. Currie,Emily S. Sena,Sabrina Ramnarine,Robin Grant,Malcolm R. Macleod,Leslie A. Colvin,Marie Fallon +7 more
TL;DR: A systematic review of studies reporting the prevalence of Chemotherapy‐induced peripheral neuropathy identified 31 studies with data from 4179 patients and identified a number of genetic and clinical risk factors that require further study.
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Mechanisms of Chemotherapy-Induced Peripheral Neuropathy.
Renata Zajączkowska,Magdalena Kocot-Kępska,Wojciech Leppert,Anna Wrzosek,Joanna Mika,Jerzy Wordliczek +5 more
TL;DR: A better understanding of the risk factors and underlying mechanisms of CIPN is needed to develop effective preventive and therapeutic strategies and the neurotoxicity mechanisms of the most common antineoplastic agents are reviewed.
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Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
Hana Starobova,Irina Vetter +1 more
TL;DR: This review focusses on the commonly used antineoplastic substances oxaliplatin, cisPlatin, vincristine, docetaxel, and paclitaxel which interfere with the cancer cell cycle—leading to cell death and tumor degradation—and cause severe acute and chronic peripheral neuropathies.
References
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Journal ArticleDOI
Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.
Hong-Hee Won,Hong-Hee Won,Jeeyun Lee,Joon Oh Park,Young Suk Park,Ho Yeong Lim,Won Ki Kang,Jong-Won Kim,Soo-Youn Lee,Se Hoon Park +9 more
TL;DR: The authors performed a genome‐wide association analysis of patients with colon cancer who received oxaliplatin‐based chemotherapy to identify potential genetic markers for severe oxaliPlatin‐induced chronic peripheral neuropathy (OXCPN).
Journal ArticleDOI
Histology and platinum content of sensory ganglia and sural nerves in patients treated with cisplatin and carboplatin: an autopsy study.
TL;DR: The hypothesis that cisplatin neuropathy is a neuroneopathy rather than a dying‐back axonopathy is supported, at least so in liver, sensory ganglia and sural nerves.
Journal ArticleDOI
Erythropoietin protects sensory axons against paclitaxel-induced distal degeneration
TL;DR: In an animal model of paclitaxel-induced distal sensory polyneuropathy, recombinant human erythropoietin protects against distal axonal degeneration and this effect is associated with downregulation of detyrosinated tubulin.
Journal ArticleDOI
Limited Access Trial Using Amifostine for Protection Against Cisplatin- and Three-Hour Paclitaxel–Induced Neurotoxicity: A Phase II Study of the Gynecologic Oncology Group
David H. Moore,James P. Donnelly,William P. McGuire,Lois Almadrones,David Cella,Thomas J. Herzog,Steven E. Waggoner +6 more
TL;DR: Amifostine's level of activity in this trial was insufficient to warrant further study in a phase III trial, and it would appear that VPT measurements are less sensitive to the development of peripheral neuropathy than the neurotoxicity questionnaire.
Journal ArticleDOI
Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients.
Jessica A. Boyette-Davis,Juan P. Cata,Haijun Zhang,Larry C. Driver,Gwen Wendelschafer-Crabb,William R. Kennedy,Patrick M. Dougherty +6 more
TL;DR: The results of this article indicate a persistent, painful peripheral neuropathy in patients treated with bortezomib and pilot data indicates a loss of nerve fibers innervating the area of pain.
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