Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Acetyl-L-carnitine undervalued in the treatment of chemotherapy-induced peripheral neuropathy?
TL;DR: To ensure correct data collection throughout a trial, time and efforts must be invested to make study participants aware of the value of the information they provide with questionnaires on the definition of the overall benefit-harm profile of a new treatment.
Journal ArticleDOI
Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity.
M. Akif Durak,Onural Ozhan,Azibe Yildiz,Merve Durhan,Nigar Vardi,Yilmaz Cigremis,Hakan Parlakpinar +6 more
TL;DR: Benefits were obtained in reducing neurotoxicity with short-term TQ application in rats treated with CIS treatment and the severity of tau protein's immunoreactivity was similar to that of the CIS-group.
Journal ArticleDOI
Emerging platinum(0) nanotherapeutics for efficient cancer therapy.
TL;DR: In this article , the challenges of traditional Pt-based chemotherapy have been outlined, and the combinations of Pt(0) nanotherapeutics with other therapeutical modalities are introduced.
Dissertation
Investigating chemotherapy induced peripheral neuropathy (CIPN) and its treatment, using functional Magnetic Resonance Imaging (fMRI)
TL;DR: A systematic review of studies reporting the prevalence of chemotherapy-induced peripheral neuropathy found that although CIPN prevalence decreases with time, at 6 months 30% of patients continue to suffer from CIP n, and routine CIPn surveillance during post-chemotherapy follow-up is needed.
Journal ArticleDOI
Gut microbiota in chronic pain: Novel insights into mechanisms and promising therapeutic strategies.
Liping Liu,Qinfen Wu,Yuping Chen,Hui-Yun Ren,Qi Zhang,Hengyue Yang,Wenying Zhang,Tingyu Ding,Shu-juan Wang,Yan Zhang,Yun Jiang Liu,Jihu Sun +11 more
TL;DR: In this paper , the authors attempted to systematically summarize the action of the gut microbiota toward regulating the pathological mechanisms of chronic pain and discussed the beneficial effects of probiotics supplementation or fecal microbiota transplantation (FMT) to restore the Gut microbiota in chronic pain patients.
References
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