Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Therapeutic benefits of maintaining mitochondrial integrity and calcium homeostasis by forced expression of Hsp27 in chemotherapy-induced peripheral neuropathy.
TL;DR: It is suggested that preserving myelin and mitochondrial integrity as well as maintaining intracellular calcium homeostasis is beneficial for preventing CIPN, and these findings shed new light on the development of anti-CIPN drugs.
Journal ArticleDOI
Exploring the Potential Role of the Gut Microbiome in Chemotherapy-Induced Neurocognitive Disorders and Cardiovascular Toxicity.
TL;DR: In this article, the authors summarized the current understanding of preclinical and clinical findings regarding the emerging role of the microbiome and the microbiota-gut-brain axis in chemotherapy-related late effects affecting the central nervous system (CNS) and heart functions.
Journal ArticleDOI
Drug Repositioning for the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: A Mechanism- and Screening-Based Strategy.
Shota Yamamoto,Nobuaki Egashira +1 more
TL;DR: In this article, the authors reviewed the known pathogenic mechanisms of oxaliplatin-and paclitaxel-induced CIPN, highlighting recent findings, and also focused on drug repositioning studies, especially for prevention.
Journal ArticleDOI
Thymoquinone prevents cisplatin neurotoxicity in primary DRG neurons.
TL;DR: TQ significantly increases the ability to extend neurites and neuronal cell viability when compared to the culture conditions which were treated with cisplatin only, and further detailed investigations in preclinical settings are warranted for its clinical use.
Journal ArticleDOI
Measuring Therapy-Induced Peripheral Neuropathy: Preliminary Development and Validation of the Treatment-Induced Neuropathy Assessment Scale
Tito R. Mendoza,Xin Shelley Wang,Loretta A. Williams,Qiuling Shi,Elisabeth G. Vichaya,Patrick M. Dougherty,Sheeba K. Thomas,Emre Yucel,Christel C. Bastida,Jeanie F. Woodruff,Charles S. Cleeland +10 more
TL;DR: It is suggested that the nonpainful components of neuropathy may be more disabling than the pain component during cancer treatment, and the development of a neuropathy assessment scale that follows regulatory guidance for patient-reported outcomes is detailed.
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