Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis.
Marta Seretny,Gillian L. Currie,Emily S. Sena,Sabrina Ramnarine,Robin Grant,Malcolm R. Macleod,Leslie A. Colvin,Marie Fallon +7 more
TL;DR: A systematic review of studies reporting the prevalence of Chemotherapy‐induced peripheral neuropathy identified 31 studies with data from 4179 patients and identified a number of genetic and clinical risk factors that require further study.
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Mechanisms of Chemotherapy-Induced Peripheral Neuropathy.
Renata Zajączkowska,Magdalena Kocot-Kępska,Wojciech Leppert,Anna Wrzosek,Joanna Mika,Jerzy Wordliczek +5 more
TL;DR: A better understanding of the risk factors and underlying mechanisms of CIPN is needed to develop effective preventive and therapeutic strategies and the neurotoxicity mechanisms of the most common antineoplastic agents are reviewed.
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Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
Hana Starobova,Irina Vetter +1 more
TL;DR: This review focusses on the commonly used antineoplastic substances oxaliplatin, cisPlatin, vincristine, docetaxel, and paclitaxel which interfere with the cancer cell cycle—leading to cell death and tumor degradation—and cause severe acute and chronic peripheral neuropathies.
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Journal ArticleDOI
Impact of oxaliplatin-induced neuropathy: a patient perspective
Barbara Bennett,Susanna B. Park,Cindy S.-Y. Lin,Michael Friedlander,Matthew C. Kiernan,David Goldstein +5 more
TL;DR: The monitoring of oxaliplatin-induced neurotoxicity would benefit from more informative clinical assessment, with inclusion of patient-reported outcome measures, in a clinical trial setting to monitor the efficacy of interventions and in prospective studies of survivorship.
Journal ArticleDOI
Cisplatin neuropathy: clinical course and neurophysiological findings
M LoMonaco,Margherita Milone,Anna Paola Batocchi,Luca Padua,Domenico Restuccia,Pietro Attilio Tonali +5 more
TL;DR: Clinical and neurophysiological signs of severity progression were noted up to 6 months after treatment with CDDP.
Journal ArticleDOI
Oxaliplatin-related neurotoxicity: interest of calcium-magnesium infusion and no impact on its efficacy.
Laurence Gamelin,Michèle Boisdron-Celle,Alain Morel,Anne Lise Poirier,Virginie Berger,Erick Gamelin,Christophe Tournigand,Aimery de Gramont +7 more
TL;DR: Ca and Mg infusion as chelators of oxalate to inhibit its action on Na channels could show in a retrospective study a dramatic decrease of acute and chronic neurotoxicity, with no impact on oxaliplatin efficacy.
Journal ArticleDOI
A prospective surveillance model for physical rehabilitation of women with breast cancer: chemotherapy-induced peripheral neuropathy.
Michael D. Stubblefield,Michael D. Stubblefield,Margaret L. McNeely,Catherine M. Alfano,Deborah K. Mayer +4 more
TL;DR: The prospective surveillance model offers promise in addressing and minimizing both the acute and long‐term morbidity associated with CIPN, and promotes a patient‐centered approach to care.
Journal Article
Amitriptyline in the prevention of chemotherapy-induced neuropathic symptoms.
TL;DR: Amitriptyline does not prevent chemotherapy-induced neuropathy and there was no difference in the appearance of chemotherapy- induced neuropathic symptoms between the groups.
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