Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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American Cancer Society Colorectal Cancer Survivorship Care Guidelines
Khaled El-Shami,Kevin C. Oeffinger,Nicole L. Erb,Anne Willis,Jennifer K. Bretsch,Mandi Pratt-Chapman,Rachel S. Cannady,Sandra L. Wong,Johnie Rose,April Barbour,Kevin Stein,Katherine Sharpe,Durado Brooks,Rebecca Cowens-Alvarado +13 more
TL;DR: In this paper, the authors present guidelines to assist primary care clinicians in delivering risk-based health care for colorectal cancer survivors who have completed active therapy, including communication and coordination of care between the treating oncologist and the primary care clinician to effectively manage the long-term care of CRC survivors.
Journal ArticleDOI
Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain
TL;DR: The failure of previously tested antioxidants, neuroprotective agents, anticonvulsants and antidepressants as therapeutic or preventative strategies are discussed, and individualized, mechanism-based therapeutic options for CIPNP associated with each of the three main drug groups are suggested.
Journal ArticleDOI
Chemotherapy-induced peripheral neurotoxicity
Guido Cavaletti,Paola Marmiroli +1 more
TL;DR: Clinical research is to standardize CIPN assessment to maintain a high level of attention to the possible neurotoxicity of drugs more recently introduced into clinical practice and to identify druggable targets for pharmacological intervention in order to prevent or limit CIPn.
Journal ArticleDOI
Metal Drugs and the Anticancer Immune Response.
Bernhard Englinger,Christine Pirker,Petra Heffeter,Alessio Terenzi,Alessio Terenzi,Christian R. Kowol,Christian R. Kowol,Bernhard K. Keppler,Bernhard K. Keppler,Walter Berger +9 more
TL;DR: This review summarizes the promising but still extremely fragmentary knowledge on the interplay of metal drugs with the fidelity of anticancer immune responses but also their role in adverse effects and highlights that, at least in some cases, metal drugs can induce long-lasting antic cancer immune responses.
Journal ArticleDOI
ROS-modulated therapeutic approaches in cancer treatment.
Muhammad Hassan Raza,Sami Siraj,Abida Arshad,Usman Waheed,Fahad M. Aldakheel,Shatha A. Alduraywish,Muhammad Arshad +6 more
TL;DR: This review highlights oxidative stress in tumors, underlying mechanisms of different relationships of ROS and cancer cells, different ROS-mediated therapeutic strategies and the emerging role of microbiota in cancer therapy.
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