Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Excessive spinal glutamate transmission is involved in oxaliplatin-induced mechanical allodynia: A possibility for riluzole as a prophylactic drug
Shota Yamamoto,Soichiro Ushio,Nobuaki Egashira,Takehiro Kawashiri,Shohei Mitsuyasu,Hitomi Higuchi,Nana Ozawa,Ken Masuguchi,Yuko Ono,Satohiro Masuda +9 more
TL;DR: The results suggest that oxaliplatin disrupts the extracellular glutamate homeostasis in the spinal cord, which may result in neuropathic symptoms, and support the use of riluzole for prophylaxis of oxali platin-induced mechanical allodynia.
Journal ArticleDOI
Differences in symptom clusters identified using symptom occurrence rates versus severity ratings in patients with breast cancer undergoing chemotherapy.
Carmen Ward Sullivan,Heather Leutwyler,Laura B. Dunn,Bruce A. Cooper,Steven M. Paul,Yvette P. Conley,Jon D. Levine,Christine Miaskowski +7 more
TL;DR: Identification of symptom clusters in patients with breast cancer may be useful in guiding symptom management interventions and future studies are warranted to determine if symptom clusters remain stable over a cycle of CTX.
Journal ArticleDOI
Quantitative assessment of chemotherapy‐induced peripheral neurotoxicity using a point‐of‐care nerve conduction device
Ayumu Matsuoka,Ayako Mitsuma,Osamu Maeda,Hiroaki Kajiyama,Hitoshi Kiyoi,Yasuhiro Kodera,Masato Nagino,Hidemi Goto,Yuichi Ando +8 more
TL;DR: Differences in the severity of CIPN could be detected objectively and quantitatively using this point‐of‐care nerve conduction device, previously validated for the assessment of diabetic peripheral neuropathy.
Journal ArticleDOI
Targeting Delivery of Lidocaine and Cisplatin by Nanogel Enhances Chemotherapy and Alleviates Metastasis
TL;DR: The results demonstrate the coloading of lidocaine and cisplatin by ligand-modified nanogels is a promising strategy for αvβ3 integrin-overexpressing breast cancer combinational therapy.
Journal ArticleDOI
The genetic variants underlying breast cancer treatment-induced chronic and late toxicities: a systematic review.
TL;DR: Most studies failed to conform to the major criteria listed in the STREGA guidelines, with a lack of transparent reporting of methods and results.
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