Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Can exercise prevent the onset of chemotherapy-induced peripheral neuropathy?
TL;DR: In this paper, a randomised control study of the efficacy of strength or balance exercise to prevent the onset and severity of chemotherapy-induced peripheral neuropathy (CIPN) was conducted.
Journal ArticleDOI
Wearables, sensors, and smart devices for the detection and monitoring of chemotherapy‐induced peripheral neurotoxicity: Systematic review and directions for future research
Elisa Mantovani,Florenc Demrozi,Daniel L. Hertz,Cristian Turetta,Omar Ferro,Andreas A. Argyriou,Graziano Pravadelli,Stefano Tamburin +7 more
TL;DR: Data are promising and provide preliminary evidence on wearables, sensors, and smart devices for CIPN detection and monitoring and a framework for future studies is proposed.
Posted ContentDOI
Protease-Activated Receptor 2 (PAR2) expressed in sensory neurons contributes to signs of pain and neuropathy in paclitaxel treated mice
Moeno Kume,Ayesha Ahmad,Kathryn DeFea,J. A. Vagner,Gregory Dussor,Scott Boitano,Theodore J. Price +6 more
TL;DR: In this paper , the role of Protease-activated receptor 2 (PAR2) expressed in sensory neurons in a paclitaxel (PTX)-induced model of CIPN in mice was demonstrated.
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