Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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ROS Modulator Molecules with Therapeutic Potential in Cancers Treatments
Carole Nicco,Frédéric Batteux +1 more
TL;DR: Various molecules that modulate ROS production/detoxification and have a synergistic action with the chemotherapies to kill cancer cells while preserving normal cells to avoid anticancer drugs side effects are reviewed, allowing a better therapeutic index of the anticancer treatments.
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Cannabinoid Type 2 Receptor System Modulates Paclitaxel-Induced Microglial Dysregulation and Central Sensitization in Rats.
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Oxidized Lipids in Persistent Pain States.
Tabea Osthues,Marco Sisignano +1 more
TL;DR: The underlying molecular mechanisms of the oxidized linoleic acid metabolites and eicosanoids are discussed and critically evaluate their role as potential targets for the development of novel analgesics and for the treatment of persistent or neuropathic pain.
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Chemotherapy-Associated Peripheral Neuropathy in Patients With Early-Stage Breast Cancer: A Systematic Review.
TL;DR: There is a paucity of data describing persistent PN in ESBC patients, and consistent use of validated measures and well-conducted randomized clinical trials or observational studies are needed to evaluate the incidence, persistence, and QOL associated with the long-term effects of PN.
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A Comparative Review of Chemotherapy-Induced Peripheral Neuropathy in In Vivo and In Vitro Models:
TL;DR: In vivo and in vitro models of CIPN are reviewed with a focus on histopathological changes and morphological features aimed at understanding the pathophysiology of C IPN and identify gaps requiring deeper exploration.
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