Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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The impact of cold therapy on the incidence and severity of paclitaxel induced peripheral neuropathy: A pilot study
TL;DR: Cold therapy appears to be feasible and appears to have some potential to prevent Paclitaxel induced peripheral neuropathy in this pilot study and the role of cold therapy may be further explored and confirmed in future randomized trials.
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A 3D model-based simulation of demyelination to understand its effects on diffusion tensor imaging
TL;DR: A 3D virtual model capable of simulating the complex Brownian motion of water molecules in a bundle of myelinated axons and glial cells for the purpose of synthesizing DTI data, characterizing and verifying the impact of demyelination on DTI is presented.
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Neutrophil extracellular traps as a unique target in the treatment of chemotherapy-induced peripheral neuropathy
Chaoyu Wang,Tong-Tong Lin,Liang Hu,Chen-Jie Xu,Fan Hu,Li Wang,Xing Yang,Xue-Feng Wu,Xiao-Tao Zhang,Yan Li,Hao Yin,Chun-Yi Jiang,H. Xin,Wen-Tao Liu +13 more
TL;DR: In this paper , the role of microcirculation hypoxia induced by neutrophil extracellular traps (NETs) in the development of CIPN and look for potential treatment.
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Review Article "Spotlight on Ultrasonography in the Diagnosis of Peripheral Nerve Disease: The Evidence to Date".
TL;DR: In this article, the authors examined the evidence supporting neuromuscular ultrasound in the diagnosis of compressive mononeuropathies, traumatic nerve injury, generalised peripheral neuropathy and motor neuron disease.
Journal ArticleDOI
Assessing chemotherapy-induced peripheral neuropathy with patient reported outcome measures: a systematic review of measurement properties and considerations for future use
Tiffany Li,Susanna B. Park,Eva Battaglini,Madeleine King,Matthew C. Kiernan,David Goldstein,Claudia Rutherford +6 more
TL;DR: In this paper , a systematic review was conducted to identify literature assessing measurement properties of CIPN patient reported outcome measures (PROMs) with consideration of fit for purpose PROMs with considerations necessarily differing when used in various research and inclinic contexts.
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