Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Research advances in nanomedicine applied to the systemic treatment of colorectal cancer
TL;DR: A review summarizes recent research performed on nanocarriers in in vivo and in vitro models and the synergistic anticancer effects of nanoccarriers, focusing on the interaction between NPs and the body, resulting in enhanced efficacy and immune activation.
Book ChapterDOI
Boron and Boron-Containing Compounds Toxicity
TL;DR: In this paper , the authors explained the toxic effect mechanisms of boron and its compounds on body systems, and the use of disinfectant and cleaning products containing borons as sprays, fertilizers, etc., during the Covid-19 pandemic also increases the interest in this issue.
Book ChapterDOI
Medications Used for Cancer
TL;DR: This chapter discusses systemic anti-cancer therapies and their use in the treatment of cancer with a particular focus on traditional cytotoxic chemotherapy.
Journal ArticleDOI
Physical activity behaviors in cancer survivors treated with neurotoxic chemotherapy
David Mizrahi,David Goldstein,Terry Trinh,Tiffany Li,Hannah C. Timmins,Michelle Harrison,Gavin Marx,Elizabeth Hovey,Craig R. Lewis,Michael Friedlander,Susanna B. Park +10 more
TL;DR: Cancer survivors exposed to neurotoxic chemotherapy have low physical activity levels, and further work should examine the factors causing physical activity limitations in this cohort and designing interventions to improve physical function and quality of life in survivors.
Journal ArticleDOI
Co-designing a cancer care intervention: reflections of participants and a doctoral researcher on roles and contributions
Mary Anne Lagmay Tanay,Jocelyn W. Armes,Catherine Oakley,Lesley Sage,Deb Tanner,Jose Roca,Liz Bryson,Barbara Greenall,Lauren Urwin,Toni Wyatt,Glenn Robert +10 more
TL;DR: In this paper , the authors explored how participants in an Experience-Based Co-Design (EBCD) project came to perceive their role and involvement in co-designing a cancer care intervention, and found that participants perceived their involvement as a positive experience with clinicians also reporting wider positive impacts on their clinical practice.
References
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