Chemotherapy-induced peripheral neurotoxicity: a critical analysis.
Susanna B. Park,David Goldstein,Arun V. Krishnan,Cindy S.-Y. Lin,Michael Friedlander,James T. Cassidy,Martin Koltzenburg,Matthew C. Kiernan +7 more
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TLDR
This review will address the increasing importance and challenge of chemotherapy‐induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers.Abstract:
With a 3-fold increase in the number of cancer survivors noted since the 1970s, there are now over 28 million cancer survivors worldwide. Accordingly, there is a heightened awareness of long-term toxicities and the impact on quality of life following treatment in cancer survivors. This review will address the increasing importance and challenge of chemotherapy-induced neurotoxicity, with a focus on neuropathy associated with the treatment of breast cancer, colorectal cancer, testicular cancer, and hematological cancers. An overview of the diagnosis, symptomatology, and pathophysiology of chemotherapy-induced peripheral neuropathy will be provided, with a critical analysis of assessment strategies, neuroprotective approaches, and potential treatments. The review will concentrate on neuropathy associated with taxanes, platinum compounds, vinca alkaloids, thalidomide, and bortezomib, providing clinical information specific to these chemotherapies. CA Cancer J Clin 2013;63:419-437. ©2013 American Cancer Society, Inc.read more
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Lived experiences and support needs of women who developed chemotherapy-induced peripheral neuropathy following treatment for breast and ovarian cancer
Mary Anne Lagmay Tanay,Jo Armes +1 more
TL;DR: The need for interventions to guide cancer survivors to recognise and report CIPN symptoms early and address the impact of CIPn symptoms in their lives is suggested.
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Nursing knowledge, practice patterns, and learning preferences regarding chemotherapy-induced peripheral neuropathy.
Ellen M. Lavoie Smith,Grace Campbell,Cindy Tofthagen,Lisa A. Kottschade,Mary Collins,Charlene Warton,Bidisha Ghosh,David L. Ronis,Gail Mallory,Constance Visovsky +9 more
TL;DR: Nurses do not consistently integrate evaluation and management of CIPN in their practices, and recommend that educational offerings should incorporate web-based CIPn assessment and management content.
Charcot-Marie-Tooth gene, SBF2, associated with taxaneinduced peripheral neuropathy in African Americans
Bryan P. Schneider,Dongbing Lai,Fei Shen,Guanglong Jiang,Milan Radovich,Lang Li,Laura Gardner,Kathy D. Miller,Anne O'Neill,Joseph A. Sparano,Gloria Xue,Tatiana Foroud,George W. Sledge +12 more
TL;DR: In this article, a whole exome sequencing was performed using germline DNA from 213 African Americans who received a standard dose and schedule of paclitaxel in the adjuvant, randomized phase III breast cancer trial, E5103.
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Cardiovascular Autonomic Dysfunction in Patients with Cancer
Ben G T Coumbe,John D. Groarke +1 more
TL;DR: Multiple risk factors predispose oncology patients to autonomic dysfunction, which is associated with adverse outcomes, including increased mortality, exercise limitation, and fatigue among this cohort.
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Effectiveness of Acupuncture Treatment on Chemotherapy-Induced Peripheral Neuropathy: A Pilot, Randomized, Assessor-Blinded, Controlled Trial.
Somayeh Iravani,Amir Hooman Kazemi Motlagh,Seyede Zahra Emami Razavi,Farhad Shahi,Jing Wang,Li Hou,Wenjun Sun,Mohammad Reza Afshari Fard,Mahdi Aghili,Mehrdad Karimi,Hossein Rezaeizadeh,Baixiao Zhao +11 more
TL;DR: This study revealed that acupuncture, as a kind of traditional Chinese therapeutic method, is significantly effective and safe in the treatment of CIPN and is more effective than using vitamin B1 and gabapentin as the conventional treatment.
References
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