Journal ArticleDOI
Circulating miRNAs in nontumoral liver diseases
Alex Evangelista do Amaral,Julia Cisilotto,Tânia Beatriz Creczynski-Pasa,Leonardo de Lucca Schiavon +3 more
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TLDR
This review of studies involving circulating miRNAs sourced from the serum or plasma of patients with nontumoral liver diseases in attempt to bring insights in the use of miRNAAs as biomarkers for diagnosis, as well as for prognosis of such diseases.About:
This article is published in Pharmacological Research.The article was published on 2017-10-14. It has received 20 citations till now. The article focuses on the topics: Liver disease.read more
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miR-27a-3p protects against blood–brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11
Tianyang Xi,Feng Jin,Ying Zhu,Jialu Wang,Ling Tang,Yanzhe Wang,David S Liebeskind,Fabien Scalzo,Zhiyi He +8 more
TL;DR: It is concluded that application of exogenous miR-27a-3p may protect against post-ICH complications by targeting AQP11 in the capillary endothelial cells of the brain.
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Breast milk microRNAs harsh journey towards potential effects in infant development and maturation. Lipid encapsulation can help.
Joao Tomé-Carneiro,Noelia Fernández-Alonso,Cristina Tomás-Zapico,Francesco Visioli,Eduardo Iglesias-Gutiérrez,Alberto Dávalos +5 more
TL;DR: This review is focused on the thorny path breast milk miRNAs face towards confirmation as relevant role players in infants' development and maturation, taking into consideration the research carried out so far on the uptake, gastrointestinal barriers and potential biological effects of diet‐derived mi RNAs.
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Overview of microRNA-199a Regulation in Cancer.
TL;DR: The biological functions of miR-199a are summarized and recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism are reviewed.
Journal ArticleDOI
Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues.
Micaela Gliozzi,Vincenzo Musolino,Francesca Bosco,Miriam Scicchitano,Federica Scarano,Saverio Nucera,Maria Caterina Zito,Stefano Ruga,Cristina Carresi,Roberta Macrì,Lorenza Guarnieri,Jessica Maiuolo,Annamaria Tavernese,Anna Rita Coppoletta,Caterina Nicita,Rocco Mollace,Ernesto Palma,Carolina Muscoli,Catherine Belzung,Vincenzo Mollace +19 more
TL;DR: The role of cholesterol homeostasis in health and disease is clarified highlighting new intriguing aspects of the cross talk between its central and peripheral metabolism.
Journal ArticleDOI
MicroRNA-126-3p Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Regulating VCAM-1 Expression.
Xi Fu,Tiesheng Niu,Xiaodong Li +2 more
TL;DR: In this paper, the authors explored the mechanism of miR-126-3p in alleviating brain injury after intracerebral hemorrhage and compared between patients with IHC and healthy controls.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
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The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
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Normalization of Real-Time Quantitative Reverse Transcription-PCR Data: A Model-Based Variance Estimation Approach to Identify Genes Suited for Normalization, Applied to Bladder and Colon Cancer Data Sets
TL;DR: A novel, innovative, and robust strategy to identify stably expressed genes among a set of candidate normalization genes, rooted in a mathematical model of gene expression, that provides a direct measure for the estimated expression variation, enabling the user to evaluate the systematic error introduced when using the gene.