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Journal ArticleDOI

Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target

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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.
Abstract
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.

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Citations
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Journal ArticleDOI

Different Grades of Collateral Circulation for Evaluating Cerebral Hemodynamic Status in Carotid Artery Stenosis

TL;DR: Overall, severity of CS is poorly related to hemodynamic status while the perfectibility of compensation defined by grades of collateral circulation effectively alleviates ipsilateral cerebral perfusion deficit in carotid NO.
Journal ArticleDOI

Association of 24-hour blood pressure parameters post-thrombectomy with functional outcomes according to collateral status

TL;DR: In this paper , the authors performed a retrospective chart review of patients who underwent mechanical thrombectomy (MT) at a comprehensive stroke center from 7/2014 to 12/2020, and determined the association of 24-h post-MT BP parameters with clinical outcomes depending on the pre-MT collateral status.
Book ChapterDOI

Aneurysm Treatment with Flow Diverters

TL;DR: Flow diversion is an effective method to treat many types of brain aneurysms, and a focus on complication avoidance is necessary to make it an even safer option for patients.
Journal ArticleDOI

Successful Leptomeningeal Enhancement in a Patient with Tandem Occlusion of a Carotid and Middle Cerebral Artery Following Carotid Artery Stenting for Contralateral Carotid Artery Stenosis

TL;DR: In this paper , the presence of leptomeningeal anastomosis is known as a predictor of favorable outcome in patients with acute large vessel occlusion, but the efficacy of enhancing leptomeneal collateral flow has rarely been demonstrated.
Journal ArticleDOI

Clinico-topographic evaluation of anterior versus posterior acute ischemic stroke and correlation with early mortality-based scale prediction

Esra Unal
- 01 Apr 2023 - 
TL;DR: In this article , the relevance of objective scales to early disability and mortality was investigated in terms of clinico-radiological and demographic aspects, and the importance of early mortality prediction was investigated.
References
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Journal ArticleDOI

Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment

TL;DR: The TOAST stroke subtype classification system is easy to use and has good interobserver agreement and should allow investigators to report responses to treatment among important subgroups of patients with ischemic stroke.
Journal ArticleDOI

Thresholds in cerebral ischemia - the ischemic penumbra.

J Astrup, +2 more
- 01 Nov 1981 - 
TL;DR: Recent evidence indicates that immediate failure of basic functions such as synaptic transmission, ion pumping and energy metabolism in the ischemic brain, is critically dependent on residual blood flow, and that these functions fail at certain critical flow thresholds.
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