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Journal ArticleDOI

Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target

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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.
Abstract
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.

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Journal ArticleDOI

Imaging in Acute Anterior Circulation Ischemic Stroke: Current and Future

Hyun Jeong Kim, +1 more
- 04 Feb 2022 - 
TL;DR: Examination of imaging methods and criteria to select eligible patients for revascularization treatment in acute anterior circulation stroke, focus on 2019 guidelines from the American Heart Association/American Stroke Association, and discuss the future direction of imaging-based patient selection to improve treatment effects are reviewed.
Journal ArticleDOI

Temporary application of lower body positive pressure improves intracranial velocities in symptomatic acute carotid occlusion or tight stenosis: A pilot study

TL;DR: In this article, isolated cervical carotid artery occlusion not eligible to recanalization therapies but with compromised intracranial hemodynamics may be at risk of further clinical event.

Influence du positionnement en décubitus déclive sur l’évolution neurologique précoce à la phase aiguë d’un infarctus cérébral supra-tentoriel avec occlusion intra-crânienne

TL;DR: Le DD semble avoir un interet dans la prise en charge aigue des infarctus cerebraux avec occlusion intracrânienne supra-tentorielle.
Journal ArticleDOI

Hemodynamic characteristics of suspected stroke in the emergency department

TL;DR: The study demonstrates the feasibility of defining hemodynamic phenotypes of ED patients with suspected stroke, and identified three phenotypic clusters based on low or normal cardiac index and normal or high systemic vascular resistance index.
References
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Journal ArticleDOI

Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment

TL;DR: The TOAST stroke subtype classification system is easy to use and has good interobserver agreement and should allow investigators to report responses to treatment among important subgroups of patients with ischemic stroke.
Journal ArticleDOI

Thresholds in cerebral ischemia - the ischemic penumbra.

J Astrup, +2 more
- 01 Nov 1981 - 
TL;DR: Recent evidence indicates that immediate failure of basic functions such as synaptic transmission, ion pumping and energy metabolism in the ischemic brain, is critically dependent on residual blood flow, and that these functions fail at certain critical flow thresholds.
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