Journal ArticleDOI
Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.Abstract:
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.read more
Citations
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Journal ArticleDOI
Assessment of neurovascular dynamics during transient ischemic attack by the novel integration of micro-electrocorticography electrode array with functional photoacoustic microscopy.
Yu Hang Liu,Lun-De Liao,Lun-De Liao,Stacey Tan,Ki Yong Kwon,Ji Min Ling,Aishwarya Bandla,Yen-Yu Ian Shih,Eddie Tung Wee Tan,Wen Li,Wai Hoe Ng,Hsin Yi Lai,You Yin Chen,Nitish V. Thakor,Nitish V. Thakor +14 more
TL;DR: A novel system combining a 16-channel micro-electrocorticography electrode array and functional photoacoustic microscopy to examine changes in neurovascular functions following transient ischemic attack in rats found transient ischemia led to increased neural activity when the relative CBV was reduced.
Journal ArticleDOI
A more consistent intraluminal rhesus monkey model of ischemic stroke
Bo Zhao,Guowei Shang,Jian Chen,Xiaokun Geng,Xin Ye,Guoxun Xu,Ju Wang,Jiasheng Zheng,Hongjun Li,Fauzia Akbary,Shengli Li,Jing Lu,Feng Ling,Xunming Ji +13 more
TL;DR: Findings indicate that reversible middle cerebral artery occlusion can be produced with the endovascular microcoil technique in rhesus monkeys and offers the potential for application in the field of brain injury research.
Journal ArticleDOI
Rapamycin Increases Collateral Circulation in Rodent Brain after Focal Ischemia as detected by Multiple Modality Dynamic Imaging.
Jixian Wang,Xiaojie Lin,Zhihao Mu,Fanxia Shen,Linyuan Zhang,Qing Xie,Yaohui Tang,Yongting Wang,Zhijun Zhang,Guo-Yuan Yang +9 more
TL;DR: Evidence of collateral functional perfusion in the skull base, deep brain, and surface of the cortex is provided, and administration of rapamycin at 15 min after MCAO dilated the existing collateral vessels and promoted collateral perfusion.
Journal ArticleDOI
Cerebral collateral flow defines topography and evolution of molecular penumbra in experimental ischemic stroke.
Simone Beretta,E Cuccione,A Versace,Davide Carone,Matteo Riva,Giada Padovano,Valentina Dell'Era,Ruiyao Cai,Laura Monza,Luca Presotto,David Rousseau,Fabien Chauveau,Giovanni Paternò,G. Pappadà,Carlo Giussani,Erik P. Sganzerla,Carlo Ferrarese +16 more
TL;DR: In this paper, the authors investigate the pattern of collateral flow with regard to penumbral tissue after transient middle cerebral artery (MCA) occlusion in rats, and show that functional performance of intracranial collaterals during MCA occlusions inversely correlated with HSP70 immunoreactive areas in both the cortex and the striatum, as well as with infarct size and functional deficit.
Book ChapterDOI
Laser Speckle Contrast Imaging to Measure Changes in Cerebral Blood Flow
TL;DR: Methods for LSCI of cerebral blood flow via a thin skull imaging preparation in mice or rats are described, which allows precise semiquantitative mapping of changes in blood flow over time using straightforward surgical protocols and equipment.
References
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Journal Article
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence F. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F. M. Wijdicks +15 more
TL;DR: The goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke.
Journal ArticleDOI
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence M. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I. Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F.M. Wijdicks +15 more
TL;DR: In this paper, the authors provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke and provide information for healthcare policy makers.
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