Journal ArticleDOI
Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.Abstract:
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.read more
Citations
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Journal ArticleDOI
A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke
Chelsea S. Kidwell,Reza Jahan,Jeffrey Gornbein,Jeffry R. Alger,Val Nenov,Zahra Ajani,Lei Feng,Brett C. Meyer,Scott E Olson,Scott E Olson,Lee H. Schwamm,Albert J Yoo,Randolph S. Marshall,Philip M. Meyers,Dileep R. Yavagal,Max Wintermark,Judy Guzy,Sidney Starkman,Jeffrey L. Saver +18 more
TL;DR: A favorable penumbral pattern on neuroimaging did not identify patients who would differentially benefit from endovascular therapy for acute ischemic stroke, nor was embolectomy shown to be superior to standard care.
Journal ArticleDOI
Pathogenic mechanisms following ischemic stroke
TL;DR: The underlying pathophysiology of ischemic stroke is reviewed and the intertwined pathways that are promising therapeutic targets are revealed, leading to the development of numerous agents that target various injury pathways.
Journal ArticleDOI
Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans
Glen C. Jickling,Dazhi Liu,Boryana Stamova,Bradley P. Ander,Xinhua Zhan,Aigang Lu,Frank R. Sharp +6 more
TL;DR: Though remarkable advances in understanding of HT have been made, additional efforts are needed to translate these discoveries to the clinic and reduce the impact of HT on patients with ischemic stroke.
Journal ArticleDOI
Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials.
Jialing Liu,Yongting Wang,Yosuke Akamatsu,Chih Cheng Lee,R. Anne Stetler,Michael T. Lawton,Guo-Yuan Yang +6 more
TL;DR: In this paper, the early phase of cerebral blood volume (CBV) increase is likely due to the improvement in collateral flow, also known as arteriogenesis, whereas the late phase of CBV increase is attributed to the surge of angiogenesis.
Journal ArticleDOI
Blood Flow Distribution in Cerebral Arteries
TL;DR: A new method is described to outline the flow profile of the cerebral vascular tree, including reference values, and should be used for grading the collateral flow system.
References
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Journal ArticleDOI
Glial and neuronal control of brain blood flow.
David Attwell,Alastair M. Buchan,Serge Charpak,Martin Lauritzen,Brian A. MacVicar,Eric A. Newman +5 more
TL;DR: It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles.
Journal ArticleDOI
Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy.
Alan Ward,Stephen P. Clissold +1 more
TL;DR: Pentoxifylline offers a well-tolerated and effective alternative to the treatment options available for patients with peripheral vascular disease and in isolated studies proved to be superior to drugs such as co-dergocrine mesylate, adenosine and pyrithioxine.
Journal ArticleDOI
Trial Design and Reporting Standards for Intra-Arterial Cerebral Thrombolysis for Acute Ischemic Stroke
Randall T. Higashida,Anthony J. Furlan,Heidi C. Roberts,Thomas Tomsick,Buddy Connors,John D. Barr,William P. Dillon,Steven Warach,Joseph P. Broderick,Barbara C. Tilley,David Sacks +10 more
TL;DR: This document serves to standardize reporting terminology and includes pretreatment assessment, neurologic evaluation with the NIH Stroke Scale score, imaging evaluation, occlusion sites, perfusion grades, follow-up imaging studies, and neurologic assessments, and suggestions for uniform reporting standards for such trials.
Journal ArticleDOI
The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke.
TL;DR: It is believed that the Lausanne Stroke Registry is the first registry with complete computed tomography and Doppler ultrasonography data on all patients, which allows correlation between clinical findings, presumed etiology, and stroke location.
Journal ArticleDOI
Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study.
Gregory W. Albers,Vincent Thijs,Lawrence R. Wechsler,Stephanie Kemp,Gottfried Schlaug,Elaine Skalabrin,Roland Bammer,Wataru Kakuda,Maarten G Lansberg,Ashfaq Shuaib,William Coplin,Scott Hamilton,Michael E. Moseley,Michael P. Marks +13 more
TL;DR: For stroke patients treated 3 to 6 hours after onset, baseline MRI findings can identify subgroups that are likely to benefit from reperfusion therapies and can potentially identify sub groups that are unlikely to benefit or may be harmed.
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