Journal ArticleDOI
Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
Reads0
Chats0
TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.Abstract:
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.read more
Citations
More filters
Proceedings ArticleDOI
Computer-aided diagnosis of acute ischemic stroke based on cerebral hypoperfusion using 4D CT angiography
TL;DR: The feasibility of a Computer-aided Diagnosis system capable of objectively predicting patient outcome is investigated and the presented CAD could make an important contribution to acute ischemic stroke diagnosis and treatment.
Journal ArticleDOI
Neuropeptide α-Melanocyte-Stimulating Hormone Promotes Neurological Recovery and Repairs Cerebral Ischemia/Reperfusion Injury in Type 1 Diabetes.
Rajesh Kumar Goit,Tsz Chung Ng,Ka Cheung Tam,Jessica K W Tsang,Andrew W. Taylor,Amy C. Y. Lo +5 more
TL;DR: In this paper, α-Melanocyte-stimulating hormone (α-MSH) is a neuropeptide that has protective effects against ischemia/reperfusion (I/R) induced organ damages.
Journal ArticleDOI
PHACTR1 genetic variability is not critical in small vessel ischemic disease patients and PcomA recruitment in C57BL/6J mice.
Clemens Messerschmidt,Marco Foddis,Sonja Blumenau,Susanne Müller,Kajetan Bentele,Manuel Holtgrewe,Celia Kun-Rodrigues,Isabel Alonso,Maria Carmo Macário,Ana Morgadinho,Ana Graça Velon,Gustavo C. Santo,Isabel Santana,Saana Mönkäre,Saana Mönkäre,Liina Kuuluvainen,Johanna Schleutker,Minna Pöyhönen,Liisa Myllykangas,Assunta Senatore,Daniel Berchtold,Katarzyna Winek,Andreas Meisel,Aleksandra M. Pavlović,Vladimir S. Kostic,Valerija Dobricic,Valerija Dobricic,Ebba Lohmann,Ebba Lohmann,Ebba Lohmann,Hasmet Hanagasi,Gamze Guven,Başar Bilgiç,Jose Bras,Rita Guerreiro,Dieter Beule,Ulrich Dirnagl,Celeste Sassi,Celeste Sassi +38 more
TL;DR: In this paper, the authors applied exome and genome sequencing in a multi-ethnic cohort of 180 early-onset independent familial and apparently sporadic brain small vessel ischemic disease and CADASIL-like Caucasian patients from US, Portugal, Finland, Serbia and Turkey and in 2 C57BL/6J stroke mouse models (bilateral common carotid artery stenosis [BCCAS] and middle cerebral artery occlusion [MCAO]), characterized by different degrees of PcomAs patency.
Journal ArticleDOI
Prognostic Value of Cystatin C in Acute Ischemic Stroke Patients with Intravenous Thrombolysis.
TL;DR: Higher levels of serum cystatin C in AIS patients after IVT were independently associated with increased risks of poor functional outcomes and vascular events, especially combining conventional risk factors, suggesting that serum cyStatin C might improve risk prediction for the poor prognosis in Ais patients receiving rt-PA treatment.
Journal ArticleDOI
Anti-inflammatory α-Melanocyte-Stimulating Hormone Protects Retina After Ischemia/Reperfusion Injury in Type I Diabetes
TL;DR: Investigation of the protective role of α-MSH on I/R-induced diabetic retinal damage using hyperglycemic C57BL/6J Ins2Akita/+ mice showed beneficial effects, which may have important therapeutic implications against retinal ischemia/reperfusion injury underhyperglycemic condition.
References
More filters
Journal ArticleDOI
Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment
Harold P. Adams,Birgitte H. Bendixen,L J Kappelle,José Biller,Betsy B. Love,David Lee Gordon,E. Eugene Marsh +6 more
TL;DR: The TOAST stroke subtype classification system is easy to use and has good interobserver agreement and should allow investigators to report responses to treatment among important subgroups of patients with ischemic stroke.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2010 Update A Report From the American Heart Association
Donald M. Lloyd-Jones,Robert J. Adams,Todd M. Brown,Mercedes R. Carnethon,Shifan Dai,Giovanni de Simone,T. Bruce Ferguson,Earl S. Ford,Karen L. Furie,Cathleen Gillespie,Alan S. Go,Kurt J. Greenlund,Nancy Haase,Susan M. Hailpern,P. Michael Ho,Virginia J. Howard,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Lynda D. Lisabeth,Ariane Marelli,Mary M. McDermott,James B. Meigs,Dariush Mozaffarian,Michael E. Mussolino,Graham Nichol,Véronique L. Roger,Wayne D. Rosamond,Ralph L. Sacco,Paul D. Sorlie,Randall S. Stafford,Thomas Thom,Sylvia Wasserthiel-Smoller,Nathan D. Wong,Judith Wylie-Rosett +34 more
TL;DR: The Statistical Update brings together the most up-to-date statistics on heart disease, stroke, other vascular diseases, and their risk factors and presents them in its Heart Disease and Stroke Statistical Update each year.
Journal ArticleDOI
Thresholds in cerebral ischemia - the ischemic penumbra.
TL;DR: Recent evidence indicates that immediate failure of basic functions such as synaptic transmission, ion pumping and energy metabolism in the ischemic brain, is critically dependent on residual blood flow, and that these functions fail at certain critical flow thresholds.
Journal Article
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence F. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F. M. Wijdicks +15 more
TL;DR: The goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke.
Journal ArticleDOI
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence M. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I. Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F.M. Wijdicks +15 more
TL;DR: In this paper, the authors provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke and provide information for healthcare policy makers.
Related Papers (5)
Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
William J. Powers,Alejandro A. Rabinstein,Teri Ackerson,Opeolu Adeoye,Nicholas C. Bambakidis,Kyra J. Becker,José Biller,Michael D. Brown,Bart M. Demaerschalk,Brian L. Hoh,Edward C. Jauch,Chelsea S. Kidwell,Thabele M Leslie-Mazwi,Bruce Ovbiagele,Phillip A. Scott,Kevin N. Sheth,Andrew M. Southerland,Deborah V. Summers,David L. Tirschwell +18 more