Journal ArticleDOI
Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.Abstract:
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.read more
Citations
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Journal ArticleDOI
CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage
Jordi Pedragosa,Angélica Salas-Perdomo,Mattia Gallizioli,Roger Cugota,Francesc Miró-Mur,Ferran Briansó,Carles Justicia,Fernando J. Pérez-Asensio,Leonardo Márquez-Kisinousky,Xabier Urra,Anna Gieryng,Bozena Kaminska,A. Chamorro,Anna M. Planas +13 more
TL;DR: Findings show ischemia-induced reprogramming of the gene expression profile of CD163+ macrophages that has a rapid impact on leukocyte chemotaxis and blood-brain barrier integrity, and promotes neurological impairment in the acute phase of stroke.
Journal ArticleDOI
Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke
Anja Nitzsche,Marine Poittevin,Ammar Benarab,Philippe Bonnin,Giuseppe Faraco,Hiroki Uchida,Julie Favre,Lidia Garcia-Bonilla,Manuela Cl Garcia,Pierre-Louis Leger,Patrice Therond,Thomas Mathivet,Gwennhael Autret,Véronique Baudrie,Ludovic Couty,Mari Kono,Aline Chevallier,Hira Niazi,Pierre-Louis Tharaux,Jerold Chun,Susan R. Schwab,Anne Eichmann,Bertrand Tavitian,Richard L. Proia,Christiane Charriaut-Marlangue,Teresa Sanchez,Nathalie Kubis,Daniel Henrion,Costantino Iadecola,Timothy Hla,Eric Camerer +30 more
TL;DR: Genetic evidence is provided to support a pivotal role for the endothelium in maintaining perfusion and microvascular patency in the ischemic penumbra that is coordinated by S1P signaling and can be harnessed for neuroprotection with BBB-penetrating S 1P1 agonists.
Journal ArticleDOI
Comparison of four different collateral scores in acute ischemic stroke by CT angiography
TL;DR: Compared with the Christoforidis and Miteff scores, the modified ASITN/SIR and ASPECTS collateral scores showed consistently higher correlation with the extent of early infarct core and mismatch volume.
Journal ArticleDOI
The Detrimental Effect of Aging on Leptomeningeal Collaterals in Ischemic Stroke
Ethem Murat Arsava,Atay Vural,Erhan Akpinar,Rahsan Gocmen,Seray Akcalar,Kader Karli Oguz,Mehmet Akif Topcuoglu +6 more
TL;DR: There is a significant interplay between patient age and adequacy of leptomeningeal collateral circulation in patients with proximal MCA occlusion that could contribute to adverse tissue outcome and thereby to unfavorable clinical outcome observed in elderly patients with ischemic stroke.
Journal ArticleDOI
Cardiovascular risk factors cause premature rarefaction of the collateral circulation and greater ischemic tissue injury
TL;DR: Chronic CVRF presence caused collateral rarefaction and worse ischemic injury, even at relatively young ages and was associated with increased proliferation rate of collateral endothelial cells, effects that may promote accelerated endothelial cell senescence.
References
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Journal Article
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence F. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F. M. Wijdicks +15 more
TL;DR: The goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke.
Journal ArticleDOI
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence M. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I. Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F.M. Wijdicks +15 more
TL;DR: In this paper, the authors provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke and provide information for healthcare policy makers.
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