Journal ArticleDOI
Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.Abstract:
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.read more
Citations
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Long-Term Risk Factors for Intracranial In-Stent Restenosis From a Multicenter Trial of Stenting for Symptomatic Intracranial Artery Stenosis Registry in China.
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FLAIR vascular hyperintensities and functional outcome in nonagenarians with anterior circulation large-vessel ischemic stroke treated with endovascular thrombectomy
Imad Derraz,Raed Ahmed,Amel Benali,Lucas Corti,F. Cagnazzo,Cyril Dargazanli,Gregory Gascou,Carlos Riquelme,Pierre-Henri Lefevre,Alain Bonafe,Caroline Arquizan,Vincent Costalat +11 more
TL;DR: In this article, the authors evaluated functional outcome with the modified Rankin scale (mRS) at 3 months in nonagenarians undergoing endovascular thrombectomy (EVT) in a prospectively maintained institutional registry of consecutive stroke patients from January 2012 to December 2018.
Journal ArticleDOI
Magnetic Resonance Perfusion Imaging Provides a Significant Tool for the Identification of Cardioembolic Stroke
Chun-Hsien Lin,Yuan-Hsiung Tsai,Jiann-Der Lee,Hsu-Huei Weng,Jen-Tsung Yang,Leng-Chieh Lin,Ya-Hui Lin,Chih-Ying Wu,Ying-Chih Huang,Huan-Lin Hsu,Meng Lee,Chia-Yu Hsu,Yi-Ting Pan,Yen-Chu Huang +13 more
TL;DR: Perfusion MRI could be a reliable tool to identify cardioembolic stroke with its lower collateral and could be used to reveal the exact mechanism and provide supportive evidence to classify a stroke.
Journal ArticleDOI
An Integrated Analysis of Risk Factors of Cognitive Impairment in Patients with Severe Carotid Artery Stenosis.
Ru Tao Luo,Pei Jiong Wang,Xiao Feng Deng,Shu Jie Zhou,Meng Zhao,Jing Qian,Dong Zhang,Rong Wang,Yan Zhang +8 more
TL;DR: A history of cerebral infarction and abnormal cerebral perfusion are associated with decline in overall cognitive function and memory in patients with carotid stenosis and being female and having an educational background above high school may be protective factors in the development of cognitive dysfunction.
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Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice.
Michael Bieber,Michael K. Schuhmann,Alexander M. Kollikowski,David Stegner,Bernhard Nieswandt,Mirko Pham,Guido Stoll +6 more
TL;DR: In this paper, the activatory platelet receptor glycoprotein (GP)VI was shown to substantially delay the progression of acute ischemic stroke by blocking platelet activation during vessel occlusion.
References
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Journal Article
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence F. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F. M. Wijdicks +15 more
TL;DR: The goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke.
Journal ArticleDOI
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence M. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I. Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F.M. Wijdicks +15 more
TL;DR: In this paper, the authors provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke and provide information for healthcare policy makers.
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