Journal ArticleDOI
Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.Abstract:
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.read more
Citations
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Journal ArticleDOI
Cerebral Venous Oxygen Saturation in Hypoperfusion Regions May Become a New Imaging Indicator to Predict the Clinical Outcome of Stroke
Fengqiu Cao,Mingming Wang,Shengyu Fan,Shanhua Han,Yingwei Guo,A. Zaman,Jia Guo,Yu Luo,Yan Kang +8 more
TL;DR: Based on quantitative susceptibility mapping and perfusion-weighted imaging, the cerebral SvO2 in hypoperfusion tissues and its change after intraarterial rt-PA treatment was analyzed using an independent t-test as mentioned in this paper .
Proceedings ArticleDOI
Transmission of photons in mouse brain using Monte Carlo method: simulation study
TL;DR: In this article, the transmission of photons in mouse brain was studied using Monte Carlo method, and the photon distribution without intact skull went farther in both longitudinal and transverse directions compared with that of with intact skull.
Journal ArticleDOI
[Endothelial sphingosine 1-phosphate signaling maintains perfusion of the cerebral cortex in ischemic stroke].
Proceedings ArticleDOI
Visualization of light transmission in the brain using photon tracking based on the Monte Carlo method
Rui Wang,Xiaohai Yu,Xianlin Song +2 more
TL;DR: In this article, the transmission of photons in mouse brain was studied using Monte Carlo method, and the photon distribution without intact skull went farther in both longitudinal and transverse directions compared with that of with intact skull.
Journal ArticleDOI
Systematic Analysis of RNA Expression Profiles in Different Ischemic Cortices in MCAO Mice
TL;DR: The present study reported the specific changes of ceRNAs in distinct compensatory regions potentially involved in the evolution of cerebral ischemic tissues and the unbalance prognosis after stroke, and provided more evidence for the collateral compensatory effects on patients' prognosis and carried out the new targets for the isChemic stroke therapy.
References
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Journal Article
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence F. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F. M. Wijdicks +15 more
TL;DR: The goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke.
Journal ArticleDOI
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence M. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I. Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F.M. Wijdicks +15 more
TL;DR: In this paper, the authors provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke and provide information for healthcare policy makers.
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