Journal ArticleDOI
Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.Abstract:
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.read more
Citations
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Journal ArticleDOI
A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke
Chelsea S. Kidwell,Reza Jahan,Jeffrey Gornbein,Jeffry R. Alger,Val Nenov,Zahra Ajani,Lei Feng,Brett C. Meyer,Scott E Olson,Scott E Olson,Lee H. Schwamm,Albert J Yoo,Randolph S. Marshall,Philip M. Meyers,Dileep R. Yavagal,Max Wintermark,Judy Guzy,Sidney Starkman,Jeffrey L. Saver +18 more
TL;DR: A favorable penumbral pattern on neuroimaging did not identify patients who would differentially benefit from endovascular therapy for acute ischemic stroke, nor was embolectomy shown to be superior to standard care.
Journal ArticleDOI
Pathogenic mechanisms following ischemic stroke
TL;DR: The underlying pathophysiology of ischemic stroke is reviewed and the intertwined pathways that are promising therapeutic targets are revealed, leading to the development of numerous agents that target various injury pathways.
Journal ArticleDOI
Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans
Glen C. Jickling,Dazhi Liu,Boryana Stamova,Bradley P. Ander,Xinhua Zhan,Aigang Lu,Frank R. Sharp +6 more
TL;DR: Though remarkable advances in understanding of HT have been made, additional efforts are needed to translate these discoveries to the clinic and reduce the impact of HT on patients with ischemic stroke.
Journal ArticleDOI
Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials.
Jialing Liu,Yongting Wang,Yosuke Akamatsu,Chih Cheng Lee,R. Anne Stetler,Michael T. Lawton,Guo-Yuan Yang +6 more
TL;DR: In this paper, the early phase of cerebral blood volume (CBV) increase is likely due to the improvement in collateral flow, also known as arteriogenesis, whereas the late phase of CBV increase is attributed to the surge of angiogenesis.
Journal ArticleDOI
Blood Flow Distribution in Cerebral Arteries
TL;DR: A new method is described to outline the flow profile of the cerebral vascular tree, including reference values, and should be used for grading the collateral flow system.
References
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Journal ArticleDOI
Clinical cerebrovascular anatomy
TL;DR: This methodical review of cerebrovascular anatomy and stroke syndromes will provide the operator with the tools to conduct a thorough neurological assessment prior to revascularization, evaluate any periprocedural complications that may arise, and evaluate the patient with suspected stroke.
Journal Article
Neuroprotection from the collateral perspective.
TL;DR: Combined revascularization and neuroprotection that take into consideration the collateral perspective may ultimately determine the fate of neuroprotection in acute ischemic stroke.
Journal ArticleDOI
Late Stimulation of the Sphenopalatine-Ganglion in Ischemic Rats: Improvement in N-Acetyl-Aspartate Levels and Diffusion Weighted Imaging Characteristics as Seen by MR
TL;DR: The ability of electrical stimulation of the sphenopalatine ganglion to augment stroke recovery in transient middle cerebral artery occluded (t‐MCAO) rats is assessed by MR spectroscopy and diffusion weighted imaging.
Journal ArticleDOI
An electron microscopic study of intimal cushions in intracranial arteries of the cat.
TL;DR: Intercellular contacts between smooth muscle cells are observed within cushions as well as in the media, suggesting that cushions may be contractile and capable of modifying cerebral blood flow.
Journal ArticleDOI
Susceptibility of Tmax to tracer delay on perfusion analysis: quantitative evaluation of various deconvolution algorithms using digital phantoms
Kohsuke Kudo,Makoto Sasaki,Leif Østergaard,Soren Christensen,Ikuko Uwano,Masako Suzuki,Kuniaki Ogasawara,Hiroki Shirato,Akira Ogawa +8 more
TL;DR: The time-to-maximum of the tissue residue function (T max) perfusion index has proven very predictive of infarct growth in large clinical trials, yet its dependency on simple tracer delays remains unknown.
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