Journal ArticleDOI
Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.Abstract:
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.read more
Citations
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Pial Collateral Reactivity During Hypertension and Aging Understanding the Function of Collaterals for Stroke Therapy
TL;DR: These results suggest that therapeutic opening of pial collaterals is possible during middle cerebral artery occlusion to create penumbral tissue and prevent infarct expansion and show for the first time that LMAs from young and aged SHR are vasoconstricted and have impaired vasodilatory responses that may contribute to greater perfusion deficit and little penumbrals.
Journal ArticleDOI
The role of CD44 in pathological angiogenesis.
TL;DR: The current understanding of the roles of CD44 in pathological angiogenesis and the underlying cellular and molecular mechanisms are summarized.
Journal ArticleDOI
Prognostic Evaluation Based on Cortical Vein Score Difference in Stroke
Rajsrinivas Parthasarathy,Mahesh Kate,Jeremy L. Rempel,David S Liebeskind,Thomas Jeerakathil,Kenneth Butcher,Ashfaq Shuaib +6 more
TL;DR: Venous features on computed tomography angiography provide additional characterization of collateral perfusion and prognostication in acute ischemic stroke and accurately predicts clinical outcomes.
Journal ArticleDOI
Collateral circulation in acute stroke: Assessing methods and impact: A literature review
Edouard Martinon,Pierre Henry Lefevre,Pierre Thouant,Guy Victor Osseby,Frédéric Ricolfi,Adrien Chavent +5 more
TL;DR: A literature review of studies evaluating collaterals at the acute phase of a carotid territory ischemic stroke found dynamic CT angiography to be the most appropriate modality.
Journal ArticleDOI
Improving the Evaluation of Collateral Circulation by Multiphase Computed Tomography Angiography in Acute Stroke Patients Treated with Endovascular Reperfusion Therapies.
Álvaro García-Tornel,Vanessa Carvalho,Sandra Boned,Alan Flores,David Rodriguez-Luna,Jorge Pagola,Marian Muchada,Estela Sanjuan,Pilar Coscojuela,Jesus Juega,Noelia Rodriguez-Villatoro,Bijoy K Menon,Mayank Goyal,Marc Ribó,Alejandro Tomasello,Carlos A. Molina,Marta Rubiera +16 more
TL;DR: CC evaluation by mCTA is a better prognostic marker than CC evaluation by sCTA for clinical and functional endpoints in acute stroke patients treated with endovascular thrombectomy.
References
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TL;DR: The TOAST stroke subtype classification system is easy to use and has good interobserver agreement and should allow investigators to report responses to treatment among important subgroups of patients with ischemic stroke.
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Journal Article
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence F. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F. M. Wijdicks +15 more
TL;DR: The goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke.
Journal ArticleDOI
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence M. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I. Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F.M. Wijdicks +15 more
TL;DR: In this paper, the authors provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke and provide information for healthcare policy makers.
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