Journal ArticleDOI
Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.Abstract:
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.read more
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Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). A single-arm feasibility study evaluating the safety and potential benefit of the Ischemic Stroke System for treatment of acute ischemic stroke.
Dheeraj Khurana,Subhash Kaul,Dietmar Schneider,Attila Csanyi,Ilona Adam,Nasli R Ichaporia,Bernd Griewing,László Csiba,Attila Valikovics,Vinod Puri,Hans-Christoph Diener,Stefan Schwab,Andreas Hetzel,Natan M. Bornstein +13 more
TL;DR: The implantation procedure and the SPG stimulation, initiated within 24hr from stroke onset, are feasible, safe, and tolerable and call for a follow-up randomized trial.
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Infarct morphology assessment in patients with carotid artery/middle cerebral artery occlusion using fast fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH)
TL;DR: The scores and locations of FVH could be a predictive imaging marker for infarct morphology in patients with symptomatic ICA or MCA occlusion.
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Corneal nerve loss as a surrogate marker for poor pial collaterals in patients with acute ischemic stroke.
Adnan Khan,Ajay Menon,Naveed Akhtar,Saadat Kamran,Ahmad Muhammad,Georgios Ponirakis,Hoda Gad,Ioannis N. Petropoulos,Faisal Wadiwala,Blessy Babu,Adeeb M. Narangoli,Pablo Garcia Bermejo,Hanadi Al Hamad,Marwan Ramadan,Peter W.R. Woodruff,Peter W.R. Woodruff,Mark Santos,Maher Saqqur,Ashfaq Shuaib,Rayaz A. Malik +19 more
TL;DR: In this article, a cross-sectional study of 35 patients with acute ischemic stroke secondary to middle cerebral artery (MCA) occlusion with poor and moderate-good pial collaterals and 35 healthy controls underwent corneal confocal microscopy and quantification of cNE and endothelial cell morphology.
Journal ArticleDOI
Application of capillary index score in predicting three-month functional outcome after endovascular treatment for acute ischemic stroke in China.
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MangMang Xu,Qian Wu,Yajun Cheng,Shuting Zhang,Wendan Tao,Shihong Zhang,Deren Wang,Ming Ren Liu,Bo Wu +8 more
TL;DR: In this article , the distribution of circle of Willis (CoW) morphology and its association with intracerebral hemorrhage (ICH) etiology and cerebral small vessel disease (CSVD) burden were assessed.
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Journal Article
Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology
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Journal ArticleDOI
Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/ American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists
Harold P. Adams,Gregory J. del Zoppo,Mark J. Alberts,Deepak L. Bhatt,Lawrence M. Brass,Anthony J. Furlan,Robert L. Grubb,Randall T. Higashida,Edward C. Jauch,Chelsea S. Kidwell,Patrick D. Lyden,Lewis B. Morgenstern,Adnan I. Qureshi,Robert H. Rosenwasser,Phillip A. Scott,Eelco F.M. Wijdicks +15 more
TL;DR: In this paper, the authors provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke and provide information for healthcare policy makers.
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