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Journal ArticleDOI

Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target

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TLDR
Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target.
Abstract
Summary Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.

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Citations
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A review of deep learning segmentation methods for carotid artery ultrasound images

TL;DR: In this paper , a review and summary of the recent research on deep learning segmentation methods for the carotid artery ultrasound images is presented. And the authors seek to identify the key trends and challenges in this field, and to provide insights into the opportunities and challenges for future research and development in this area.
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How do cardiovascular risk factors correlate with post-stroke cognitive function: Directly or indirectly through stroke severity?

TL;DR: This is the first Chinese study exploring the moderated and mediating associations between cardiovascular risk factors, stroke severity, and cognitive function after stroke and the combination of hypertension and diabetes might have a positive effect on cognition.
Journal ArticleDOI

Prognosis of ischemic stroke patients with or without collateralization after carotid stenosis

TL;DR: It can be concluded that carotid stenosed patients who suffered from ischemic stroke, most of the patients disability improved to some extents whether collateralization developed or not among the major vessels.
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A multiscale computational framework to evaluate flow alterations during mechanical thrombectomy for treatment of ischaemic stroke

TL;DR: In this paper, a multiscale computational framework is presented to simulate mechanical thrombectomy (MT) procedures and the results show the advantage of using balloon guide catheters (BGC) during MT and indicate small differences between positioning the aspiration catheter in proximal or distal locations.
References
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Journal ArticleDOI

Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment

TL;DR: The TOAST stroke subtype classification system is easy to use and has good interobserver agreement and should allow investigators to report responses to treatment among important subgroups of patients with ischemic stroke.
Journal ArticleDOI

Thresholds in cerebral ischemia - the ischemic penumbra.

J Astrup, +2 more
- 01 Nov 1981 - 
TL;DR: Recent evidence indicates that immediate failure of basic functions such as synaptic transmission, ion pumping and energy metabolism in the ischemic brain, is critically dependent on residual blood flow, and that these functions fail at certain critical flow thresholds.
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