Journal ArticleDOI
Comparative efficacy of antimalarial drugs including ACTs in the treatment of uncomplicated malaria among children under 5 years in Ghana.
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The findings are in agreement with current recommendations for using artemisinin-based combinations for treating uncomplicated malaria in areas of high CHQ failure such as Ghana.About:
This article is published in Acta Tropica.The article was published on 2005-09-01. It has received 129 citations till now. The article focuses on the topics: Amodiaquine & Artemether.read more
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Journal ArticleDOI
Artemisinin-based combination therapy for treating uncomplicated malaria.
TL;DR: Dihydroartemisinin-piperaquine is another effective first-line treatment for P. falciparum malaria and ACTs with long half-lives may provide some benefit, while the performance of the non-ACT (amodiaquine plus sulfadoxine-pyrimethamine) falls below WHO recommendations for first- line therapy in parts of Africa.
Journal ArticleDOI
Google Scholar as replacement for systematic literature searches: good relative recall and precision are not enough
TL;DR: This work measures the relative recall and precision of searches with Google Scholar under conditions which are derived from structured search procedures conventional in scientific literature retrieval; and provides an overview of current advantages and disadvantages of the Google Scholar search interface in scientific Literature retrieval.
Journal ArticleDOI
Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial
Salim Abdulla,Issaka Sagara,Steffen Borrmann,Steffen Borrmann,Umberto D'Alessandro,Raquel González,Raquel González,Mary J. Hamel,Bernhards Ogutu,Andreas Mårtensson,Andreas Mårtensson,John Lyimo,Hamma Maiga,Philip Sasi,Alain Nahum,Quique Bassat,Quique Bassat,Elizabeth Juma,Lucas Otieno,Anders Björkman,Anders Björkman,Hans-Peter Beck,Kim Andriano,Marc Cousin,Gilbert Lefèvre,David Ubben,Zulfikarali Premji +26 more
TL;DR: A six-dose regimen of artemether-lumefantrine with the new dispersible formulation is as efficacious as the currently used crushed tablet in infants and children, and has a similar safety profile.
Journal ArticleDOI
Epidemiology of malaria in the forest-savanna transitional zone of Ghana
Seth Owusu-Agyei,Kwaku Poku Asante,Martin Adjuik,George Adjei,Elizabeth Awini,Mohammed Adams,Sam Newton,David Dosoo,Dominic B Dery,Akua Agyeman-Budu,John O. Gyapong,Brian Greenwood,Daniel Chandramohan +12 more
TL;DR: The transmission of malaria in the forest-savanna region of central Ghana is high and perennial and this is an appropriate site for conducting clinical trials of anti-malarial drugs and vaccines.
Journal ArticleDOI
Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial
Issaka Zongo,Grant Dorsey,Noel Rouamba,Halidou Tinto,Christian Dokomajilar,Robert T. Guiguemdé,Philip J. Rosenthal,Jean-Bosco Ouédraogo +7 more
TL;DR: Amodiaquine plus sulfadoxine-pyrimethamine was more effective than was artemether-lumefantrine for the treatment of uncomplicated malaria and should be considered as an alternative to blanket recommendations for artemisinin-based combination treatment for malaria.
References
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Journal ArticleDOI
Averting a malaria disaster.
Nicholas J. White,François Nosten,Sornchai Looareesuwan,William M. Watkins,Kevin Marsh,Robert W. Snow,Gilbert Kokwaro,John H. Ouma,Tran Tinh Hien,Malcolm E. Molyneux,Malcolm E. Molyneux,Terrie E. Taylor,Terrie E. Taylor,Chris I. Newbold,TK Ruebush,M Danis,Brian Greenwood,Roy M. Anderson,Piero Olliaro +18 more
TL;DR: Pyrimethamine-sulphadoxine (PSD) is usually deployed as a successor to chloroquine, but resistance to PSD is increasing and a health calamity looms within the next few years.
Journal ArticleDOI
Impact of chloroquine resistance on malaria mortality
Jean-François Trape,Gilles Pison,Marie-Pierre Préziosi,Catherine Enel,Annabel Desgrées du Loû,Valérie Delaunay,Badara Samb,Emmanuel Lagarde,Jean-François Molez,François Simondon +9 more
TL;DR: Findings suggest that the spread of chloroquine resistance has had a dramatic impact on the level of malaria mortality in most epidemiological contexts in tropical Africa.
Journal ArticleDOI
Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial.
Martin Adjuik,Patrice Agnamey,Abdel Babiker,Steffen Borrmann,Steffen Borrmann,Philippe Brasseur,M. Cisse,Frank Cobelens,Diallo S,Jean-François Faucher,Paul Garner,S. Gikunda,Peter G. Kremsner,Peter G. Kremsner,Sanjeev Krishna,Sanjeev Krishna,Bertrand Lell,Bertrand Lell,M. Loolpapit,Pierre-Blaise Matsiegui,Michel A. Missinou,Michel A. Missinou,J. Mwanza,Francine Ntoumi,Piero Olliaro,P. Osimbo,Philipp Rezbach,Philipp Rezbach,Eliab Some,Walter R. J. Taylor +29 more
TL;DR: The combination of artesunate and amodiaquine improved treatment efficacy in Gabon and Kenya, and was equivalent in Sénégal, and is a potential combination for use in Africa.
Journal ArticleDOI
Artesunate Reduces but Does Not Prevent Posttreatment Transmission of Plasmodium falciparum to Anopheles gambiae
Geoffrey A. T. Targett,Chris Drakeley,Musa Jawara,Lorenz von Seidlein,Rosalind Coleman,J L Deen,Margaret Pinder,Tom Doherty,Tom Doherty,Colin J. Sutherland,Gijs Walraven,Paul Milligan +11 more
TL;DR: Questions are raised about any policy to use pyrimethamine-sulfadoxine alone as the first-line treatment for malaria, and the effect of such therapy on transmission is examined.
Journal Article
Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial (vol 355, pg 352, 2000)
L von Seidlein,Paul Milligan,Margaret Pinder,Kalifa Bojang,C Anyalebechi,Roly Gosling,R. Coleman,J I Ude,A.D. Sadiq,Manoj T. Duraisingh,D. C. Warhurst,Ali Alloueche,G. A. T. Targett,Keith P. W. J. McAdam,Brian Greenwood,G. Walraven,P Olliaoro,Tom Doherty +17 more
TL;DR: The addition of artesunate to malaria treatment regimens in Africa results in lower gametocyte rates and may lower transmission rates, and there was no additional benefit for three doses of artESunate over one dose.