Journal ArticleDOI
Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
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TLDR
The vast majority of men > or =50 years old initially diagnosed with iRBD in this study eventually developed a parkinsonian disorder/dementia, often after a prolonged interval from onset of iR BD, with the mean interval being 14 years while the range extended to 29 years.About:
This article is published in Sleep Medicine.The article was published on 2013-08-01. It has received 628 citations till now. The article focuses on the topics: REM sleep behavior disorder & Dementia with Lewy bodies.read more
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Journal ArticleDOI
REM sleep behavior disorder in Parkinson's disease.
TL;DR: The clinical aspects, screening and diagnostic criteria as well as therapeutic aspects of RBD in PD patients are reviewed and pathophysiological pathways are briefly reviewed.
Journal ArticleDOI
Neurophysiological basis of rapid eye movement sleep behavior disorder: informing future drug development
TL;DR: These findings suggest a gradual involvement of the brainstem and other structures, which is in line with the gradual involvement known in these disorders, and are proposed to help identify biomarkers of individuals at high risk of subsequent conversion to parkinsonism.
Journal ArticleDOI
Greatest rapid eye movement sleep atonia loss in men and older age.
TL;DR: Men and the elderly may be biologically predisposed to altered REM sleep muscle atonia control, and/or some may have occult neurodegenerative disease, possibly underlying the predominance of older men with REM sleep behavior disorder.
Journal ArticleDOI
REM sleep atonia loss distinguishes synucleinopathy in older adults with cognitive impairment
Stuart J. McCarter,Grace M. Tabatabai,Ho Yann Jong,David J. Sandness,Paul C. Timm,Katie Johnson,Allison R. McCarter,Allison R. McCarter,Rodolfo Savica,Prashanthi Vemuri,Mary M. Machulda,Kejal Kantarci,Michelle M. Mielke,Bradley F. Boeve,Michael H. Silber,Erik K. St. Louis +15 more
TL;DR: This study provides Class III evidence that quantitative RSWA analysis is useful for distinguishing cognitive impairment phenotypes and further studies with pathologic confirmation of dementia diagnoses are needed to confirm the diagnostic utility of RSWA in dementia.
Journal ArticleDOI
Assessing the role of nocturnal core body temperature dysregulation as a biomarker of neurodegeneration.
Arabella K. Raupach,Kaylena A. Ehgoetz Martens,Kaylena A. Ehgoetz Martens,Negar Memarian,Negar Memarian,George Zhong,George Zhong,Elie Matar,Glenda M. Halliday,Ronald R. Grunstein,Simon J.G. Lewis +10 more
TL;DR: Thermoregulatory dysfunction is implicate as a potential early biomarker for development of rapid eye movement sleep behaviour disorder‐associated neurodegeneration, and subpopulations with differing pathological underpinnings might exist in Parkinson’s disease.
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Reisa A. Sperling,Paul S. Aisen,Laurel A. Beckett,David A. Bennett,Suzanne Craft,Anne M. Fagan,Takeshi Iwatsubo,Clifford R. Jack,Jeffrey Kaye,Thomas J. Montine,Denise C. Park,Eric M. Reiman,Christopher C. Rowe,Eric Siemers,Yaakov Stern,Kristine Yaffe,Maria C. Carrillo,Bill Thies,Marcelle Morrison-Bogorad,Molly V. Wagster,Creighton H. Phelps +20 more
TL;DR: A conceptual framework and operational research criteria are proposed, based on the prevailing scientific evidence to date, to test and refine these models with longitudinal clinical research studies and it is hoped that these recommendations will provide a common rubric to advance the study of preclinical AD.
Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
Ian G. McKeith,Ian G. McKeith,Dennis W. Dickson,James Lowe,Murat Emre,John T. O'Brien,Howard Feldman,Jeffrey L. Cummings,John E. Duda,Carol F. Lippa,Elaine K. Perry,Dag Aarsland,Hiroyuki Arai,Clive Ballard,B. F. Boeve,David J. Burn,Durval C. Costa,T. Del Ser,Bruno Dubois,Douglas Galasko,Serge Gauthier,Christopher G. Goetz,Estrella Gómez-Tortosa,Glenda M. Halliday,L. A. Hansen,John Hardy,Takeshi Iwatsubo,Raj N. Kalaria,Daniel I. Kaufer,Rose Anne Kenny,Amos D. Korczyn,Kenji Kosaka,Virginia M.-Y. Lee,Andrew J. Lees,Irene Litvan,Elisabet Londos,Oscar L. Lopez,Satoshi Minoshima,Yoshikuni Mizuno,José Antonio Molina,Elizabeta B. Mukaetova-Ladinska,Florence Pasquier,Robert H. Perry,Jörg B. Schulz,John Q. Trojanowski,Masahito Yamada +45 more
TL;DR: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them as mentioned in this paper.