Journal ArticleDOI
Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
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TLDR
The vast majority of men > or =50 years old initially diagnosed with iRBD in this study eventually developed a parkinsonian disorder/dementia, often after a prolonged interval from onset of iR BD, with the mean interval being 14 years while the range extended to 29 years.About:
This article is published in Sleep Medicine.The article was published on 2013-08-01. It has received 628 citations till now. The article focuses on the topics: REM sleep behavior disorder & Dementia with Lewy bodies.read more
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Rapid Eye Movement Sleep Behavior Disorder: Abnormal Cardiac Image and Progressive Abnormal Metabolic Brain Pattern
Annette Janzen,Rosalie V. Kogan,Sanne K. Meles,Elisabeth Sittig,Remco J. Renken,Fanni F. Geibl,Jan Booij,Gilles N. Stormezand,Markus Luster,Geert Mayer,Klaus L. Leenders,Wolfgang H. Oertel +11 more
TL;DR: In this article, isolated rapid eye movement sleep behavior disorder (iRBD) was found to be prodromal for α-synucleinopathies and was associated with progressive and suprathreshold PDRP z scores.
Journal ArticleDOI
Mastering nocturnal jigsaws in Parkinson's disease: a dusk-to-dawn review of night-time symptoms.
TL;DR: This narrative review is intended to provide a practical guide on how these common night-time symptoms manifest and highlight pertinent issues by focusing on prevalence, clinical symptomatology, and specific relationships to PD.
Journal ArticleDOI
Idiopathic RBD: the role of gender.
TL;DR: A retrospective study that includes 329 consecutives idiopathic RBD patients, diagnosed according to the International Classification of Sleep Disorders 3rd Edition (ICSD-3) criteria, finds a significant gender difference in RBD-onset age and significant differences in some PSG findings.
Journal ArticleDOI
Premotor Parkinson's disease: Overview of clinical symptoms and current diagnostic methods.
Michaela Kaiserová,Zuzana Grambalova,Sandra Kurcova,Pavel Otruba,Hana Prikrylova Vranova,Katerina Mensikova,Petr Kanovsky +6 more
TL;DR: Parkinson's disease is characterized by typical motor symptoms However, recent studies show several non-motor features that may precede the development of the motor symptoms of PD.
Journal ArticleDOI
Accurate Detection of α‐Synuclein Seeds in Cerebrospinal Fluid from Isolated Rapid Eye Movement Sleep Behavior Disorder and Patients with Parkinson's Disease in the DeNovo Parkinson (DeNoPa) Cohort
Luis Concha-Marambio,Sandrina Weber,Carly M. Farris,Mohammed Dakna,Elisabeth Lang,Tamara Wicke,Yihua Ma,Maritta Starke,Jens Ebentheuer,Friederike Sixel-Döring,Maria-Lucia Muntean,Sebastian Schade,Claudia Trenkwalder,C. Soto,Brit Mollenhauer +14 more
TL;DR: Misfolded synuclein (αSyn) aggregates in cerebrospinal fluid (CSF) are biomarkers for Parkinson's disease such as PD as mentioned in this paper , and have been detected in prodromal cases with isolated rapid eye movement sleep behavior disorder (iRBD).
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Reisa A. Sperling,Paul S. Aisen,Laurel A. Beckett,David A. Bennett,Suzanne Craft,Anne M. Fagan,Takeshi Iwatsubo,Clifford R. Jack,Jeffrey Kaye,Thomas J. Montine,Denise C. Park,Eric M. Reiman,Christopher C. Rowe,Eric Siemers,Yaakov Stern,Kristine Yaffe,Maria C. Carrillo,Bill Thies,Marcelle Morrison-Bogorad,Molly V. Wagster,Creighton H. Phelps +20 more
TL;DR: A conceptual framework and operational research criteria are proposed, based on the prevailing scientific evidence to date, to test and refine these models with longitudinal clinical research studies and it is hoped that these recommendations will provide a common rubric to advance the study of preclinical AD.
Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
Ian G. McKeith,Ian G. McKeith,Dennis W. Dickson,James Lowe,Murat Emre,John T. O'Brien,Howard Feldman,Jeffrey L. Cummings,John E. Duda,Carol F. Lippa,Elaine K. Perry,Dag Aarsland,Hiroyuki Arai,Clive Ballard,B. F. Boeve,David J. Burn,Durval C. Costa,T. Del Ser,Bruno Dubois,Douglas Galasko,Serge Gauthier,Christopher G. Goetz,Estrella Gómez-Tortosa,Glenda M. Halliday,L. A. Hansen,John Hardy,Takeshi Iwatsubo,Raj N. Kalaria,Daniel I. Kaufer,Rose Anne Kenny,Amos D. Korczyn,Kenji Kosaka,Virginia M.-Y. Lee,Andrew J. Lees,Irene Litvan,Elisabet Londos,Oscar L. Lopez,Satoshi Minoshima,Yoshikuni Mizuno,José Antonio Molina,Elizabeta B. Mukaetova-Ladinska,Florence Pasquier,Robert H. Perry,Jörg B. Schulz,John Q. Trojanowski,Masahito Yamada +45 more
TL;DR: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them as mentioned in this paper.