Journal ArticleDOI
Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
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TLDR
The vast majority of men > or =50 years old initially diagnosed with iRBD in this study eventually developed a parkinsonian disorder/dementia, often after a prolonged interval from onset of iR BD, with the mean interval being 14 years while the range extended to 29 years.About:
This article is published in Sleep Medicine.The article was published on 2013-08-01. It has received 628 citations till now. The article focuses on the topics: REM sleep behavior disorder & Dementia with Lewy bodies.read more
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CD4+ T-cell Transcription Factors in Idiopathic REM Sleep Behavior Disorder and Parkinson's Disease
Erika De Francesco,Michele Terzaghi,Elisa Storelli,Luca Magistrelli,Cristoforo Comi,Massimiliano Legnaro,Marco Mauri,Franca Marino,Maurizio Versino,Marco Cosentino +9 more
TL;DR: In idiopathic rapid eye movement sleep behavior disorder subjects CD4+ T cells exhibit a peculiar molecular signature strongly resembling cells from PD patients, suggesting early involvement of peripheral immunity in PD.
Journal ArticleDOI
Apathy in Parkinson's disease with REM sleep behavior disorder
Panagiotis Bargiotas,Maria Ntafouli,M. Lenard Lachenmayer,Paul Krack,W. M. Michael Schüpbach,Claudio L. Bassetti +5 more
TL;DR: In PD, RBD is associated with isolated apathy and increased severity of depressive symptoms, independent of medication, motor and other non-motor symptoms.
Journal ArticleDOI
Smartphone Speech Testing for Symptom Assessment in Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease
TL;DR: In this paper, the authors investigated smartphone speech testing to distinguish participants with RBD from controls and PD, and predict a range of self- or researcher-administered clinical scores that quantify participants' motor symptoms, cognition, daytime sleepiness, depression, and the overall state of health.
Journal ArticleDOI
Glucocerebrosidase gene variants are accumulated in idiopathic REM sleep behavior disorder.
Ana Gámez-Valero,Alex Iranzo,Mónica Serradell,Dolores Vilas,Joan Santamaria,Carles Gaig,Ramiro Álvarez,Aurelio Ariza,Eduardo Tolosa,Katrin Beyer +9 more
TL;DR: In IRBD, GBA variants are more frequent when compared to controls but not indicative of a short-term risk for LBD after IRBD diagnosis, and could be studied with disease-modifying interventions aiming to restore the GBA metabolic pathway.
Journal ArticleDOI
Cerebral glucose metabolism in idiopathic REM sleep behavior disorder is different from tau-related and α-synuclein-related neurodegenerative disorders: A brain [18F]FDG PET study.
Claudio Liguori,Roberta Ruffini,Enrica Olivola,Agostino Chiaravalloti,Francesca Izzi,Alessandro Stefani,Mariangela Pierantozzi,Nicola Biagio Mercuri,Nicola Modugno,Diego Centonze,Orazio Schillaci,Fabio Placidi +11 more
TL;DR: The hypothesis that idiopathic REM behavior disorder may represent a very early stage of α-synucleinopathy in which biomarkers changes already occur but not allow the prediction of phenoconversion is supported.
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Reisa A. Sperling,Paul S. Aisen,Laurel A. Beckett,David A. Bennett,Suzanne Craft,Anne M. Fagan,Takeshi Iwatsubo,Clifford R. Jack,Jeffrey Kaye,Thomas J. Montine,Denise C. Park,Eric M. Reiman,Christopher C. Rowe,Eric Siemers,Yaakov Stern,Kristine Yaffe,Maria C. Carrillo,Bill Thies,Marcelle Morrison-Bogorad,Molly V. Wagster,Creighton H. Phelps +20 more
TL;DR: A conceptual framework and operational research criteria are proposed, based on the prevailing scientific evidence to date, to test and refine these models with longitudinal clinical research studies and it is hoped that these recommendations will provide a common rubric to advance the study of preclinical AD.
Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
Ian G. McKeith,Ian G. McKeith,Dennis W. Dickson,James Lowe,Murat Emre,John T. O'Brien,Howard Feldman,Jeffrey L. Cummings,John E. Duda,Carol F. Lippa,Elaine K. Perry,Dag Aarsland,Hiroyuki Arai,Clive Ballard,B. F. Boeve,David J. Burn,Durval C. Costa,T. Del Ser,Bruno Dubois,Douglas Galasko,Serge Gauthier,Christopher G. Goetz,Estrella Gómez-Tortosa,Glenda M. Halliday,L. A. Hansen,John Hardy,Takeshi Iwatsubo,Raj N. Kalaria,Daniel I. Kaufer,Rose Anne Kenny,Amos D. Korczyn,Kenji Kosaka,Virginia M.-Y. Lee,Andrew J. Lees,Irene Litvan,Elisabet Londos,Oscar L. Lopez,Satoshi Minoshima,Yoshikuni Mizuno,José Antonio Molina,Elizabeta B. Mukaetova-Ladinska,Florence Pasquier,Robert H. Perry,Jörg B. Schulz,John Q. Trojanowski,Masahito Yamada +45 more
TL;DR: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them as mentioned in this paper.