Journal ArticleDOI
Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish
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TLDR
Teleost fish are characterized by exceptionally high levels of brain estrogen biosynthesis when compared to the brains of other vertebrates or to the ovaries of the same fish, and goldfish and zebrafish have utility as complementary models for understanding the molecular basis and functional significance of exaggerated neural testosterone biosynthesis.About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2001-12-01. It has received 286 citations till now. The article focuses on the topics: Estrogen receptor beta & Estrogen receptor alpha.read more
Citations
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The Steroid Hormone Biosynthesis Pathway as a Target for Endocrine-Disrupting Chemicals
TL;DR: This review aims to provide a comprehensive overview of the state of knowledge regarding the mechanisms by which chemicals interfere with the function of steroidogenic enzymes in various tissues and organisms.
Journal ArticleDOI
The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research—Advantages and Current Limitations:
TL;DR: The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification of the roles of specific genes and signaling pathways in development, and to fully utilize the potential of zebra fish as an animal model for understanding human development, disease, and toxicology the authors must greatly advance the knowledge on zebra Fish diseases and pathology.
Journal ArticleDOI
Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish
Jared V. Goldstone,Andrew G. McArthur,Akira Kubota,Juliano Zanette,Juliano Zanette,Thiago E.M. Parente,Thiago E.M. Parente,Maria Jonsson,Maria Jonsson,David R. Nelson,John J. Stegeman +10 more
TL;DR: It is revealed that the majority of zebrafish CYP genes are expressed in embryos, with waves of expression of different sets of genes over the course of development, which provides a foundation for the use ofZebrafish as a model in toxicological, pharmacological and chemical disease research.
Journal ArticleDOI
Characterization and expression pattern of zebrafish anti-Mullerian hormone (amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development
Adriana Rodríguez-Marí,Yi-Lin Yan,Ruth Bremiller,Catherine Wilson,Cristian Cañestro,John H. Postlethwait +5 more
TL;DR: It is found that the onset of amh expression occurred while gonads were still undifferentiated and sox9a and cyp19a1a were already expressed, and the finding that zebrafishSox9b andSox8 were not co-expressed with amh in oocytes excludes the possibility that amhexpression in zebra fish granulosa cells is directly regulated by either of these two genes.
Journal ArticleDOI
Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish.
TL;DR: Diverse EDCs may affect the expression and/or activity of aromatase cyp19 genes through a variety of mechanisms, many of which need further characterization in order to improve the prediction of risks posed by a contaminated environment to teleost fish population.
References
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Journal ArticleDOI
The nuclear receptor superfamily: the second decade.
David J. Mangelsdorf,Carl S. Thummel,Miguel Beato,Peter Herrlich,Günther Schütz,Kazuhiko Umesono,Bruce Blumberg,Philippe Kastner,Manuel Mark,Pierre Chambon,Ronald M. Evans +10 more
TL;DR: This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli.
Journal ArticleDOI
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio
P. Haffter,Michael Granato,Michael Brand,Mary C. Mullins,M. Hammerschmidt,D. A. Kane,J. Odenthal,F. J. M. Van Eeden,Y.-J. Jiang,Carl-Philipp Heisenberg,Robert N. Kelsh,Makoto Furutani-Seiki,Elisabeth Vogelsang,D. Beuchle,U. Schach,C. Fabian,Christiane Nüsslein-Volhard +16 more
TL;DR: It is estimated that the 372 genes defined by the mutants probably represent more than half of all genes that could have been discovered using the criteria of the screen, and the limits and the potentials of a genetic saturation screen in the zebrafish.
Journal ArticleDOI
Estrogen actions in the central nervous system.
Bruce S. McEwen,Stephen E. Alves +1 more
TL;DR: This work has shown that estrogens, Neuroprotection, and Alzheimer’s Disease are intertwined and that the effects of estrogens on learning and memory are determined by the mechanism of action of the hormone.
Journal ArticleDOI
Aromatase Cytochrome P450, The Enzyme Responsible for Estrogen Biosynthesis*
Evan R. Simpson,Mala Mahendroo,Gary D. Means,Michael W. Kilgore,Margaret M. Hinshelwood,Sandra E. Graham-Lorence,Bilal Amarneh,Yuji Ito,Carolyn R. Fisher,M. Dodson Michael,Carole R. Mendelson,Serdar E. Bulun +11 more
TL;DR: The biosynthesis of estrogens appears to occur throughout the entire vertebrate phylum including mammals, birds, reptiles, amphibians, teleost and elasmobranch fish, and Agnatha, and in the protochordate Amphioxus.