Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder
Jennifer S. Stevens,Tanja Jovanovic,Negar Fani,Timothy D. Ely,Ebony M. Glover,Bekh Bradley,Bekh Bradley,Kerry J. Ressler,Kerry J. Ressler +8 more
TLDR
This is the first study to show that the amygdala response may be accompanied by disruption of an amygdala-vmPFC functional circuit that is hypothesized to be involved in prefrontal cortical regulation of amygdala responsivity.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Ventromedial prefrontal cortex & Amygdala.read more
Citations
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Persistent Dissociation and Its Neural Correlates in Predicting Outcomes After Trauma Exposure.
Lauren A.M. Lebois,Nathaniel G. Harnett,Sanne J.H. van Rooij,Timothy D. Ely,P. Jovanovic,Steve Bruce,Stacey L. House,Caitlin Ravichandran,Nathalie M. Dumornay,Katherine E. Finegold,Sarah B. Hill,Julia B. Merker,Karlye Phillips,Francesca L. Beaudoin,Xinming An,Thomas C. Neylan,Gari D. Clifford,Sarah D. Linnstaedt,Laura Germine,Scott L. Rauch,John P. Haran,Alan B. Storrow,C. Lewandowski,P.I. Musey,Phyllis L. Hendry,Sophia Sheikh,C. W. Jones,Brittany E. Punches,Robert A. Swor,Meghan E. McGrath,Lauren A. Hudak,J. L. Pascual,Mark J. Seamon,Elizabeth M. Datner,Anna Marie Chang,Claire Pearson,Robert M. Domeier,Niels K. Rathlev,Brian J. O'Neil,Paulina Sergot,L. D. Sanchez,Mark W. Miller,Robert H. Pietrzak,Jutta Joormann,Deanna M. Barch,Diego A. Pizzagalli,John F. Sheridan,Jordan W. Smoller,Beatriz Luna,Steven E. Harte,James Elliott,Ronald C. Kessler,Karestan C. Koenen,Samuel A. McLean,Jennifer S. Stevens,Kerry J. Ressler +55 more
TL;DR: In this article , the authors conducted the largest prospective longitudinal biomarker study of persistent dissociation to date to determine its predictive capacity for adverse psychiatric outcomes following acute trauma and found that derealization was associated with increased ventromedial prefrontal cortex activation in the emotion reactivity task and decreased resting state vmPFC connectivity with the cerebellum and orbitofrontal cortex.
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Nervous and Endocrine System Dysfunction in Posttraumatic Stress Disorder: An Overview and Consideration of Sex as a Biological Variable.
Antonia V. Seligowski,Antonia V. Seligowski,Nathaniel G. Harnett,Julia B. Merker,Kerry J. Ressler +4 more
TL;DR: An overview of the current understanding of nervous and endocrine dysfunction in PTSD is provided, highlighting areas where the influence of sex has been characterized and where further research is needed.
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Enhanced Discriminative Fear Learning of Phobia-Irrelevant Stimuli in Spider-Fearful Individuals
Carina Mosig,Christian J. Merz,Cornelia Mohr,Dirk Adolph,Oliver T. Wolf,Silvia Schneider,Jürgen Margraf,Armin Zlomuzica +7 more
TL;DR: First evidence that spider-fearful individuals show an enhanced discriminative fear learning of phobia-irrelevant (de novo) stimuli is provided, providing novel insights into the role of fear acquisition and expression for the development and maintenance of maladaptive responses in the course of SP.
Journal ArticleDOI
Genetic influences on the neural and physiological bases of acute threat: A research domain criteria (RDoC) perspective.
Jennifer A. Sumner,Jennifer A. Sumner,Abigail Powers,Tanja Jovanovic,Karestan C. Koenen,Karestan C. Koenen +5 more
TL;DR: Examination of genetic contributions to the construct of acute threat at two units of analysis within the RDoC framework focused on genetic influences on activation patterns of frontolimbic neural circuitry and on startle, skin conductance, and heart rate responses.
Journal ArticleDOI
Neuroendocrine pathways underlying risk and resilience to PTSD in women
TL;DR: Significant findings that implicate the role of estradiol, progesterone, and allopregnanolone in female risk for PTSD symptoms and dysregulation of fear psychophysiology that is cardinal to PTSD are summarized.
References
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Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
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Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults.
TL;DR: The effect size of all the risk factors was modest, but factors operating during or after the trauma, such as trauma severity, lack of social support, and additional life stress, had somewhat stronger effects than pretrauma factors.
Journal ArticleDOI
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Simon B. Eickhoff,Klaas E. Stephan,Hartmut Mohlberg,Christian Grefkes,Gereon R. Fink,Katrin Amunts,Karl Zilles +6 more
TL;DR: A new, MATLAB based toolbox for the SPM2 software package is introduced which enables the integration of probabilistic cytoarchitectonic maps and results of functional imaging studies and an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space.
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Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
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