Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder
Jennifer S. Stevens,Tanja Jovanovic,Negar Fani,Timothy D. Ely,Ebony M. Glover,Bekh Bradley,Bekh Bradley,Kerry J. Ressler,Kerry J. Ressler +8 more
TLDR
This is the first study to show that the amygdala response may be accompanied by disruption of an amygdala-vmPFC functional circuit that is hypothesized to be involved in prefrontal cortical regulation of amygdala responsivity.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Ventromedial prefrontal cortex & Amygdala.read more
Citations
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Journal ArticleDOI
A pilot study of closed-loop neuromodulation for treatment-resistant post-traumatic stress disorder
Jay Gill,Julia A. Schneiders,Matthias Stangl,Zahra M. Aghajan,Sonja Hiller,Uros Topalovic,Cory S. Inman,Diane Villaroman,Ausaf A. Bari,Avishek Adhikari,Vikram R. Rao,Michael S. Fanselow,Michelle G. Craske,Scott E. Krahl,James W. Y. Chen,Nicholas R. Hasulak,Jonathan C. Kao,Ralph J. Koek,Nanthia Suthana,Jean-Philippe Langevin +19 more
TL;DR: In this article , a first-of-its-kind pilot study, the authors recorded intracranial electroencephalographic data longitudinally (over one year) in two male individuals with amygdala electrodes implanted for the management of treatment-resistant PTSD under clinical trial NCT04152993.
Book ChapterDOI
Posttraumatic Stress Disorder: From Neurobiology to Cycles of Violence
TL;DR: It is shown how pervasive childhood and adult trauma increase risk for PTSD and associated substance abuse, depression, and aggression symptoms, contributing to cycles of violence and trauma-related disorders in at-risk communities.
Posted ContentDOI
A reciprocal inhibition model of alternations between non-dissociative and dissociative states in patients with PTSD
Toshinori Chiba,Kentaro Ide,Shuken Boku,Jessica E. Taylor,Hiroyuki Toda,Tetsufumi Kanazawa,Tetsufumi Kanazawa,Sumie Kato,Yuka Horiuchi,Akitoyo Hishimoto,Toru Maruyama,Taisuke Yamamoto,Miyako Shirakawa,Ichiro Sora,Mitsuo Kawato,Ai Koizumi +15 more
TL;DR: The hypothesis that reciprocal inhibition of common neural circuits may underlie the switch between attentional biases toward and away from threat as well as that between re-experiencing and avoidance symptoms is supported.
Posted ContentDOI
Blood-derived DNA methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women
J. Pfeiffer,Sanne J.H. van Rooij,Yara Mekawi,Negar Fani,P. Jovanovic,Vasiliki Michopoulos,Jennifer S. Stevens,Monica Uddin +7 more
TL;DR: In this article , the authors examined the associations of childhood trauma burden (CTQ), adult trauma burden, low income and low education with blood-derived 5mC clusters and variability in brain region measurements in the amygdala, hippocampus and frontal cortex subregions.
Journal ArticleDOI
Prior sexual trauma exposure impacts posttraumatic dysfunction and neural circuitry following a recent traumatic event in the AURORA study
Grace E. Rowland,Alyssa R. Roeckner,Timothy D. Ely,Lauren A.M. Lebois,Sanne J.H. van Rooij,Steve Bruce,P. Jovanovic,Stacey L. House,Francesca L. Beaudoin,Xinming An,Thomas C. Neylan,Gari D. Clifford,Sarah D. Linnstaedt,Laura Germine,Scott L. Rauch,John P. Haran,Alan B. Storrow,C. Lewandowski,P.I. Musey,Phyllis L. Hendry,Sophia Sheikh,C. W. Jones,Brittany E. Punches,Michael C. Kurz,Nina Gentile,Lauren A. Hudak,J. L. Pascual,Mark J. Seamon,Erica J. Harris,Claire Pearson,Roland C. Merchant,Robert M. Domeier,Niels K. Rathlev,Paulina Sergot,L. D. Sanchez,Mark W. Miller,Robert H. Pietrzak,Jutta Joormann,Diego A. Pizzagalli,John F. Sheridan,Jordan W. Smoller,Steven E. Harte,James M. Elliott,Ronald C. Kessler,Karestan C. Koenen,Samuel A. McLean,Kerry J. Ressler,Jennifer S. Stevens,Nathaniel G. Harnett +48 more
References
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Journal ArticleDOI
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
Journal ArticleDOI
Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults.
TL;DR: The effect size of all the risk factors was modest, but factors operating during or after the trauma, such as trauma severity, lack of social support, and additional life stress, had somewhat stronger effects than pretrauma factors.
Journal ArticleDOI
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Simon B. Eickhoff,Klaas E. Stephan,Hartmut Mohlberg,Christian Grefkes,Gereon R. Fink,Katrin Amunts,Karl Zilles +6 more
TL;DR: A new, MATLAB based toolbox for the SPM2 software package is introduced which enables the integration of probabilistic cytoarchitectonic maps and results of functional imaging studies and an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space.
Journal ArticleDOI
Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
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Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia
Amit Etkin,Tor D. Wager +1 more