Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder
Jennifer S. Stevens,Tanja Jovanovic,Negar Fani,Timothy D. Ely,Ebony M. Glover,Bekh Bradley,Bekh Bradley,Kerry J. Ressler,Kerry J. Ressler +8 more
TLDR
This is the first study to show that the amygdala response may be accompanied by disruption of an amygdala-vmPFC functional circuit that is hypothesized to be involved in prefrontal cortical regulation of amygdala responsivity.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Ventromedial prefrontal cortex & Amygdala.read more
Citations
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The Role of the Amygdala and the Ventromedial Prefrontal Cortex in Emotional Regulation: Implications for Post-traumatic Stress Disorder
TL;DR: Evidence is provided to support the role of the ventromedial prefrontal cortex (vmPFC) as a moderator and inhibitor of the amygdala and the dual inhibition model is proposed as a neuropsychological mechanism for post-traumatic stress disorder (PTSD).
Journal ArticleDOI
Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice.
TL;DR: Results show for the first time that cotinine reduces the negative effects of stress on mood, memory, and the synapses in mice subjected to prolonged restraint.
Journal ArticleDOI
Circuit dysregulation and circuit-based treatments in posttraumatic stress disorder.
Jony Sheynin,Israel Liberzon +1 more
TL;DR: This work concisely describes three functional neural circuits implicated in PTSD pathophysiology and briefly review selected treatment strategies in the context of these neural circuits.
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Genome-wide gene-based analysis suggests an association between Neuroligin 1 ( NLGN1 ) and post-traumatic stress disorder
Varun Kilaru,S V Iyer,Lynn M. Almli,Jennifer S. Stevens,Adriana Lori,Tanja Jovanovic,T.D. Ely,Bekh Bradley,Bekh Bradley,Elisabeth B. Binder,Nastassja Koen,Dan J. Stein,Karen N. Conneely,Aliza P. Wingo,Aliza P. Wingo,Alicia K. Smith,Kerry J. Ressler,Kerry J. Ressler +17 more
TL;DR: Gen-based testing to GWAS data from the Grady Trauma Project (GTP), a primarily African American cohort, and two genes are identified that associate with PTSD after multiple test correction support a contribution of the NLGN1 gene pathway to the neurobiological underpinnings of PTSD.
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Neural Correlates of Affective Disturbances: A Comparative Meta-analysis of Negative Affect Processing in Borderline Personality Disorder, Major Depressive Disorder, and Posttraumatic Stress Disorder.
TL;DR: The present results support shared and disorder-specific neural abnormalities in patients with affective disturbances, including limbic hyperactivations in BPD and PTSD compared with limbic activation of HCs.
References
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Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
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Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults.
TL;DR: The effect size of all the risk factors was modest, but factors operating during or after the trauma, such as trauma severity, lack of social support, and additional life stress, had somewhat stronger effects than pretrauma factors.
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A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Simon B. Eickhoff,Klaas E. Stephan,Hartmut Mohlberg,Christian Grefkes,Gereon R. Fink,Katrin Amunts,Karl Zilles +6 more
TL;DR: A new, MATLAB based toolbox for the SPM2 software package is introduced which enables the integration of probabilistic cytoarchitectonic maps and results of functional imaging studies and an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space.
Journal ArticleDOI
Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
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