Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder
Jennifer S. Stevens,Tanja Jovanovic,Negar Fani,Timothy D. Ely,Ebony M. Glover,Bekh Bradley,Bekh Bradley,Kerry J. Ressler,Kerry J. Ressler +8 more
TLDR
This is the first study to show that the amygdala response may be accompanied by disruption of an amygdala-vmPFC functional circuit that is hypothesized to be involved in prefrontal cortical regulation of amygdala responsivity.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Ventromedial prefrontal cortex & Amygdala.read more
Citations
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Journal ArticleDOI
Neural function during emotion processing and modulation associated with treatment response in a randomized clinical trial for posttraumatic stress disorder.
Elizabeth R. Duval,Jony Sheynin,Jony Sheynin,Anthony P. King,K. Luan Phan,Naomi M. Simon,Naomi M. Simon,Brian Martis,Brian Martis,Brian Martis,Katherine E. Porter,Sonya B. Norman,Sonya B. Norman,Israel Liberzon,Israel Liberzon,Sheila A.M. Rauch +15 more
TL;DR: It is unknown how neural circuits are associated with response to evidence‐based treatments for PTSD and how these circuits change during and after treatment.
Journal ArticleDOI
Frontal Lobe Circuitry in Posttraumatic Stress Disorder.
Lynn D. Selemon,Keith A. Young,Keith A. Young,Keith A. Young,Dianne A. Cruz,Douglas E. Williamson,Douglas E. Williamson +6 more
TL;DR: Widespread frontal lobe dysfunction in posttraumatic stress disorder provides a neurobiologic basis for the core symptomatology of the disorder, as well as for executive function impairment.
Book ChapterDOI
Cingulate subregions in posttraumatic stress disorder, chronic stress, and treatment.
TL;DR: While great strides have been made to understand better the ACC, aMCC, and PCC in both PTSD and chronic stress, additional studies are needed to determine the origin of these cingulate abnormalities and whether they can be used as biomarkers in assessing and predicting treatment response in PTSD.
Journal ArticleDOI
Threat-induced anxiety during goal pursuit disrupts amygdala-prefrontal cortex connectivity in posttraumatic stress disorder.
Delin Sun,Delin Sun,Andrea L. Gold,Andrea L. Gold,Chelsea A. Swanson,Chelsea A. Swanson,Courtney C. Haswell,Courtney C. Haswell,Vanessa M. Brown,Daniel Stjepanović,Daniel Stjepanović,Kevin S. LaBar,Kevin S. LaBar,Rajendra A. Morey,Rajendra A. Morey +14 more
TL;DR: The findings showed that veterans with PTSD have disrupted amygdala–vmPFC functional connectivity and greater localized vmPFC processing under threat modulation of goal-directed behavior, specifically related to successfully avoiding loss of monetary rewards.
Journal ArticleDOI
Brain Activity in Response to Trauma-specific, Negative, and Neutral Stimuli. A fMRI Study of Recent Road Traffic Accident Survivors
André Sevenius Nilsen,Ines Blix,Siri Leknes,Øivind Ekeberg,Laila Skogstad,Tor Endestad,Bjørn C. Østberg,Trond Heir +7 more
TL;DR: It is argued that these results might indicate an attentional sensory processing bias toward Trauma-specific stimuli for trauma exposed individuals, a result in line with findings from the post-traumatic stress disorder literature.
References
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Journal ArticleDOI
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
Journal ArticleDOI
Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults.
TL;DR: The effect size of all the risk factors was modest, but factors operating during or after the trauma, such as trauma severity, lack of social support, and additional life stress, had somewhat stronger effects than pretrauma factors.
Journal ArticleDOI
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Simon B. Eickhoff,Klaas E. Stephan,Hartmut Mohlberg,Christian Grefkes,Gereon R. Fink,Katrin Amunts,Karl Zilles +6 more
TL;DR: A new, MATLAB based toolbox for the SPM2 software package is introduced which enables the integration of probabilistic cytoarchitectonic maps and results of functional imaging studies and an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space.
Journal ArticleDOI
Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
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