Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder
Jennifer S. Stevens,Tanja Jovanovic,Negar Fani,Timothy D. Ely,Ebony M. Glover,Bekh Bradley,Bekh Bradley,Kerry J. Ressler,Kerry J. Ressler +8 more
TLDR
This is the first study to show that the amygdala response may be accompanied by disruption of an amygdala-vmPFC functional circuit that is hypothesized to be involved in prefrontal cortical regulation of amygdala responsivity.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Ventromedial prefrontal cortex & Amygdala.read more
Citations
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Functional Neuroanatomy of Emotion and Its Regulation in PTSD.
TL;DR: It is demonstrated that emotion dysregulation in PTSD arises from complications within a large neurocircuitry involving the amygdala, insula, hippocampus, anterior cingulate cortex, and prefrontal cortex, which further support the importance of studying emotion-regulation deficits in tandem with exaggerated symptom provocation in order to better understand the constellation of symptoms present in those with PTSD.
Journal ArticleDOI
Stress and Bronchodilator Response in Children with Asthma
John Brehm,Sima K. Ramratnam,Sze Man Tse,Damien C. Croteau-Chonka,Maria Pino-Yanes,Christian Rosas-Salazar,Augusto A. Litonjua,Benjamin A. Raby,Nadia Boutaoui,Yueh-Ying Han,Wei Chen,Erick Forno,Anna L. Marsland,Nicole R. Nugent,Celeste Eng,Angel Colón-Semidey,María Alvarez,Edna Acosta-Pérez,Melissa L. Spear,Fernando D. Martinez,Lydiana Avila,Scott T. Weiss,Manuel E. Soto-Quiros,Carole Ober,Dan L. Nicolae,Kathleen C. Barnes,Robert F. Lemanske,Robert C. Strunk,Andrew H. Liu,Stephanie J. London,Frank D. Gilliland,Patrick M. A. Sleiman,Michael E. March,Hakon Hakonarson,Qing Ling Duan,Jay K. Kolls,Gregory K. Fritz,Donglei Hu,Negar Fani,Jennifer S. Stevens,Lynn M. Almli,Esteban G. Burchard,Jaemin Shin,Elizabeth L. McQuaid,Kerry J. Ressler,Glorisa Canino,Juan C. Celedón +46 more
TL;DR: High child stress and an ADCYAP1R1 single-nucleotide polymorphism are associated with reduced BDR in children with asthma, likely caused by down-regulation of ADRB2 in highly stressed children.
Journal ArticleDOI
Role of social cognition in post-traumatic stress disorder: A review and meta-analysis.
TL;DR: The literature on the interaction of genes and the social environment is reviewed, supporting the hypothesis that social cognitive deficits are a preexisting risk factor for PTSD and relevant neuroimaging findings suggest that alterations in social cognition affect the perception of threat cues in PTSD.
Journal ArticleDOI
Default Mode Network Subsystems Are Differentially Disrupted in Posttraumatic Stress Disorder
Danielle R. Miller,Danielle R. Miller,Scott M. Hayes,Scott M. Hayes,Jasmeet P. Hayes,Jasmeet P. Hayes,Jeffrey M. Spielberg,Jeffrey M. Spielberg,Ginette Lafleche,Ginette Lafleche,Mieke Verfaellie,Mieke Verfaellie +11 more
TL;DR: Results suggest that selective alterations in functional connectivity in the MTL subsystem of the default mode network in PTSD may be an important factor in PTSD pathology and symptomatology.
Journal ArticleDOI
Concurrent Treatment of Substance Use and PTSD.
TL;DR: The findings from clinical trials targeting a reduction in SUD and PTSD symptoms simultaneously will be summarized to improve the knowledge base and subsequently enhance the ability to develop effective interventions for this complex comorbid condition.
References
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Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
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TL;DR: A new, MATLAB based toolbox for the SPM2 software package is introduced which enables the integration of probabilistic cytoarchitectonic maps and results of functional imaging studies and an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space.
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Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
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