Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder
Jennifer S. Stevens,Tanja Jovanovic,Negar Fani,Timothy D. Ely,Ebony M. Glover,Bekh Bradley,Bekh Bradley,Kerry J. Ressler,Kerry J. Ressler +8 more
TLDR
This is the first study to show that the amygdala response may be accompanied by disruption of an amygdala-vmPFC functional circuit that is hypothesized to be involved in prefrontal cortical regulation of amygdala responsivity.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Ventromedial prefrontal cortex & Amygdala.read more
Citations
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Vagus nerve stimulation enhances extinction of conditioned fear and modulates plasticity in the pathway from the ventromedial prefrontal cortex to the amygdala.
David F. Peña,Jessica E. Childs,Shawn M. Willett,Analicia Vital,Christa K. McIntyre,Sven Kroener +5 more
TL;DR: The present findings suggest that VNS promotes plasticity in the IL-BLA pathway to facilitate extinction of conditioned fear responses (CFRs) in rats.
Journal ArticleDOI
Complex PTSD, affect dysregulation, and borderline personality disorder
TL;DR: Clinical and scientific findings regarding comorbidity, clinical phenomenology and neurobiology of BPD, PTSD, and cPTSD, and the role of traumatic victimization, dissociation, and affect dysregulation suggest that BPD may involve heterogeneity related to psychological trauma that includes, but extends beyond, comorbridity with PTSD.
Journal ArticleDOI
PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus
Jennifer S. Stevens,Lynn M. Almli,Negar Fani,David A. Gutman,Bekh Bradley,Bekh Bradley,Seth D. Norrholm,Seth D. Norrholm,Emily Reiser,Timothy D. Ely,Rahim Dhanani,Ebony M. Glover,Tanja Jovanovic,Kerry J. Ressler,Kerry J. Ressler +14 more
TL;DR: The findings indicate that the PACAP system modulates medial temporal lobe function in humans, and individual differences in ADCYAP1R1 genotype may contribute to dysregulated fear circuitry known to play a central role in PTSD and other anxiety disorders.
Journal ArticleDOI
Distinct intrinsic network connectivity patterns of post-traumatic stress disorder symptom clusters
M. Tursich,Tomas Ros,Paul A. Frewen,Rosemarie Kluetsch,Vince D. Calhoun,Vince D. Calhoun,Ruth A. Lanius +6 more
TL;DR: This work investigated the degree of association between resting connectivity of the salience (SN), default mode (DMN), and central executive (CEN) networks and PTSD symptom severity.
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Behavioral control blunts reactions to contemporaneous and future adverse events: medial prefrontal cortex plasticity and a corticostriatal network.
TL;DR: The joint occurrence of control and adverse events seems to produce enduring plastic changes in the top–down inhibitory mPFC system such that this system is now activated by later adverse events even if they are uncontrollable, thereby reducing the impact of these events.
References
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Journal ArticleDOI
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
Journal ArticleDOI
Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults.
TL;DR: The effect size of all the risk factors was modest, but factors operating during or after the trauma, such as trauma severity, lack of social support, and additional life stress, had somewhat stronger effects than pretrauma factors.
Journal ArticleDOI
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Simon B. Eickhoff,Klaas E. Stephan,Hartmut Mohlberg,Christian Grefkes,Gereon R. Fink,Katrin Amunts,Karl Zilles +6 more
TL;DR: A new, MATLAB based toolbox for the SPM2 software package is introduced which enables the integration of probabilistic cytoarchitectonic maps and results of functional imaging studies and an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space.
Journal ArticleDOI
Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
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