Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder
Jennifer S. Stevens,Tanja Jovanovic,Negar Fani,Timothy D. Ely,Ebony M. Glover,Bekh Bradley,Bekh Bradley,Kerry J. Ressler,Kerry J. Ressler +8 more
TLDR
This is the first study to show that the amygdala response may be accompanied by disruption of an amygdala-vmPFC functional circuit that is hypothesized to be involved in prefrontal cortical regulation of amygdala responsivity.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Ventromedial prefrontal cortex & Amygdala.read more
Citations
More filters
Journal ArticleDOI
Functional connectivity of resting state EEG and symptom severity in patients with post-traumatic stress disorder.
TL;DR: Compared to controls, patients with PTSD were found to have decreased resting-state FC, and these FC measures were significantly correlated with PTSD symptom severity, suggesting that resting- state FC could be a useful biomarker for PTSD.
Journal ArticleDOI
Maternal buffering of fear-potentiated startle in children and adolescents with trauma exposure.
Sanne J.H. van Rooij,Dorthie Cross,Jennifer S. Stevens,L. Alexander Vance,Ye Ji Kim,Bekh Bradley,Nim Tottenham,Tanja Jovanovic +7 more
TL;DR: It is demonstrated that maternal availability improved discrimination in children, regardless of the quality of the relationship, suggesting that childhood may be a sensitive period for environmental influences on key processes such as learning of danger and safety signals.
Journal ArticleDOI
Increased Inhibition of the Amygdala by the mPFC may Reflect a Resilience Factor in Post-traumatic Stress Disorder: A Resting-State fMRI Granger Causality Analysis.
TL;DR: The results suggest that increased inhibition of the amygdala by the mPFC may reflect a resilience factor, and altered amygdala-SMA and amygdala-STG effective connectivity may reflect compensatory mechanisms of brain function.
Journal ArticleDOI
Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women.
Neeti D. Mehta,Jennifer S. Stevens,Zhihao Li,Charles F. Gillespie,Negar Fani,Vasiliki Michopoulos,Vasiliki Michopoulos,Jennifer C. Felger +7 more
TL;DR: Investigation of resting-state functional MRI in a high-trauma inner-city population of African-American women suggests that inflammation contributes to compromised reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women.
Journal ArticleDOI
Individual differences in behavioral and cardiovascular reactivity to emotive stimuli and their relationship to cognitive flexibility in a primate model of trait anxiety
Yoshiro Shiba,Andrea M. Santangelo,Katrin Braesicke,Carmen Agustín-Pavón,Gemma J Cockcroft,Mark Haggard,Angela C. Roberts +6 more
TL;DR: A new model of trait anxiety in marmosets amenable to analysis of phenotypic variation and neural circuitry is provided and is associated with altered prefrontal cognitive functioning in humans and rodents.
References
More filters
Journal ArticleDOI
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
TL;DR: Lifetime prevalence estimates are higher in recent cohorts than in earlier cohorts and have fairly stable intercohort differences across the life course that vary in substantively plausible ways among sociodemographic subgroups.
Journal ArticleDOI
Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults.
TL;DR: The effect size of all the risk factors was modest, but factors operating during or after the trauma, such as trauma severity, lack of social support, and additional life stress, had somewhat stronger effects than pretrauma factors.
Journal ArticleDOI
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Simon B. Eickhoff,Klaas E. Stephan,Hartmut Mohlberg,Christian Grefkes,Gereon R. Fink,Katrin Amunts,Karl Zilles +6 more
TL;DR: A new, MATLAB based toolbox for the SPM2 software package is introduced which enables the integration of probabilistic cytoarchitectonic maps and results of functional imaging studies and an easy-to-use tool for the integrated analysis of functional and anatomical data in a common reference space.
Journal ArticleDOI
Deep brain stimulation for treatment-resistant depression.
Helen S. Mayberg,Helen S. Mayberg,Andres M. Lozano,Valerie Voon,Heather E. McNeely,David A. Seminowicz,Clement Hamani,Jason M. Schwalb,Sidney H. Kennedy +8 more
TL;DR: It is suggested that disrupting focal pathological activity in limbic-cortical circuits using electrical stimulation of the subgenual cingulate white matter can effectively reverse symptoms in otherwise treatment-resistant depression.
Related Papers (5)
Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia
Amit Etkin,Tor D. Wager +1 more