Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder
Jennifer S. Stevens,Tanja Jovanovic,Negar Fani,Timothy D. Ely,Ebony M. Glover,Bekh Bradley,Bekh Bradley,Kerry J. Ressler,Kerry J. Ressler +8 more
TLDR
This is the first study to show that the amygdala response may be accompanied by disruption of an amygdala-vmPFC functional circuit that is hypothesized to be involved in prefrontal cortical regulation of amygdala responsivity.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Ventromedial prefrontal cortex & Amygdala.read more
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Trends in cognitive sciences
TL;DR: The effects of Acute, Chronic & Withdrawal from Chronic Ethanol on Emotional Learning Enhanced Odorant Preference Associative Learning in C. elegans and the study of Procedural & Episodic Memory Function in Songbirds Need Dendritic Spines.
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Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
TL;DR: This work describes the current understanding of the circuit dysfunction that underlies the symptoms of post-traumatic stress disorder and provides further insights into the mechanisms of risk and resilience.
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Restoring large-scale brain networks in PTSD and related disorders: a proposal for neuroscientifically-informed treatment interventions
TL;DR: It is suggested that each network is associated with specific clinical symptoms observed in PTSD, including cognitive dysfunction (central executive network), increased and decreased arousal/interoception (salience network), and an altered sense of self (default mode network).
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The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback.
Andrew A. Nicholson,Daniela Rabellino,Maria Densmore,Paul A. Frewen,Christian Paret,Rosemarie Kluetsch,Christian Schmahl,Jean Théberge,Richard W. J. Neufeld,Margaret C. McKinnon,Jeffrey P. Reiss,Rakesh Jetly,Ruth A. Lanius +12 more
TL;DR: This is the first demonstration of successful downregulation of the amygdala using rt‐fMRI‐nf in PTSD, which was critically sustained in a subsequent transfer run without neurofeedback, and corresponded to increased connectivity with prefrontal regions involved in emotion regulation during the intervention.
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Diagnostic Biomarkers for Posttraumatic Stress Disorder: Promising Horizons from Translational Neuroscience Research.
TL;DR: The current review provides an update to the literature with regard to the most promising putative PTSD biomarkers, with specific emphasis on the interaction between neurobiological influences on disease risk and symptom progression.
References
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Functional connectivity of the prefrontal cortex and the amygdala in posttraumatic stress disorder
TL;DR: Functional connectivity in patients with PTSD and healthy trauma survivors during repeated symptom provocation using H(2)O(15) positron emission tomography is examined to suggest that inferences of direct correspondence between animal studies and pathophysiology of PTSD should be made with caution.
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Exaggerated and Disconnected Insular-Amygdalar Blood Oxygenation Level-Dependent Response to Threat-Related Emotional Faces in Women with Intimate-Partner Violence Posttraumatic Stress Disorder
Gregory A. Fonzo,Alan N. Simmons,Alan N. Simmons,Steven R. Thorp,Steven R. Thorp,Sonya B. Norman,Sonya B. Norman,Martin P. Paulus,Martin P. Paulus,Murray B. Stein,Murray B. Stein +10 more
TL;DR: Hyperactivity of cognitive-appraisal networks in IPV-PTSD may promote hypervigilant states of awareness through an exaggerated sensitivity to contextual cues, i.e., male gender, which relate to past trauma.
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PTSD in urban primary care: high prevalence and low physician recognition.
Jane M. Liebschutz,Richard Saitz,Victoria Brower,Terence M. Keane,Terence M. Keane,Christine Lloyd-Travaglini,Tali Averbuch,Jeffrey H. Samet +7 more
TL;DR: The prevalence of PTSD in the urban primary care setting, and particularly among certain high-risk conditions, compels a critical examination of optimal approaches for screening, intervention, and referral to PTSD treatment.
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Trauma exposure, posttraumatic stress disorder and depression in an African-American primary care population
Tanya N. Alim,Elaine Graves,Thomas A. Mellman,Notalelomwan Aigbogun,Ekwenzi Gray,William Lawson,Dennis S. Charney +6 more
TL;DR: The findings suggest the importance of screening African Americans for PTSD, in addition to depression, in the primary care setting, as well as rates of MDE comorbid with PTSD, comparable to other studies.
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Posttraumatic stress disorder among African Americans in an inner city mental health clinic.
TL;DR: PTSD is a common yet underrecognized and undertreated source of psychiatric morbidity in this urban community of African Americans with low socioeconomic status.
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