Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder
Jennifer S. Stevens,Tanja Jovanovic,Negar Fani,Timothy D. Ely,Ebony M. Glover,Bekh Bradley,Bekh Bradley,Kerry J. Ressler,Kerry J. Ressler +8 more
TLDR
This is the first study to show that the amygdala response may be accompanied by disruption of an amygdala-vmPFC functional circuit that is hypothesized to be involved in prefrontal cortical regulation of amygdala responsivity.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-10-01 and is currently open access. It has received 230 citations till now. The article focuses on the topics: Ventromedial prefrontal cortex & Amygdala.read more
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Trends in cognitive sciences
TL;DR: The effects of Acute, Chronic & Withdrawal from Chronic Ethanol on Emotional Learning Enhanced Odorant Preference Associative Learning in C. elegans and the study of Procedural & Episodic Memory Function in Songbirds Need Dendritic Spines.
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Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
TL;DR: This work describes the current understanding of the circuit dysfunction that underlies the symptoms of post-traumatic stress disorder and provides further insights into the mechanisms of risk and resilience.
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Restoring large-scale brain networks in PTSD and related disorders: a proposal for neuroscientifically-informed treatment interventions
TL;DR: It is suggested that each network is associated with specific clinical symptoms observed in PTSD, including cognitive dysfunction (central executive network), increased and decreased arousal/interoception (salience network), and an altered sense of self (default mode network).
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The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback.
Andrew A. Nicholson,Daniela Rabellino,Maria Densmore,Paul A. Frewen,Christian Paret,Rosemarie Kluetsch,Christian Schmahl,Jean Théberge,Richard W. J. Neufeld,Margaret C. McKinnon,Jeffrey P. Reiss,Rakesh Jetly,Ruth A. Lanius +12 more
TL;DR: This is the first demonstration of successful downregulation of the amygdala using rt‐fMRI‐nf in PTSD, which was critically sustained in a subsequent transfer run without neurofeedback, and corresponded to increased connectivity with prefrontal regions involved in emotion regulation during the intervention.
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Diagnostic Biomarkers for Posttraumatic Stress Disorder: Promising Horizons from Translational Neuroscience Research.
TL;DR: The current review provides an update to the literature with regard to the most promising putative PTSD biomarkers, with specific emphasis on the interaction between neurobiological influences on disease risk and symptom progression.
References
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Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomography provocation study
TL;DR: Measurements of regional cerebral blood flow in a male patient with war and torture related post-traumatic stress disorder (PTSD) during symptom provocation suggest that SSRI treatment normalize provocation induced rCBF alterations in areas involved in memory, emotion, attention and motor-control.
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Functional neuroimaging of emotionally intense autobiographical memories in post-traumatic stress disorder.
TL;DR: The fMRI data suggest that there was greater recruitment and coupling of emotional brain regions during the retrieval of negatively intense AMs in the PTSD group when compared to controls.
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Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor.
Soraya Seedat,James M. Warwick,Barend B. Van Heerden,Charmaine Hugo,Nompumelelo Zungu-Dirwayi,Jeanine van Kradenburg,Dan J. Stein +6 more
TL;DR: These preliminary findings are consistent with clinical data indicating temporal and prefrontal cortical dysfunction in PTSD and preclinical data demonstrating serotonergic innervation of these regions, however, further studies are needed to confirm whether these regional abnormalities correlate with clinical features and treatment response.
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Association of Fkbp5 Polymorphisms and Childhood Abuse with Risk of Posttraumatic Stress Disorder Symptoms in Adults
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Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat.
TL;DR: The results show that it is possible to replicate findings from a clinical trial in a rodent model, and support the use of the forced swim test to gain greater understanding of the neurocircuitry involved in depression and antidepressant-action.
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