Journal ArticleDOI
Early Administration of Azathioprine vs Conventional Management of Crohn's Disease: A Randomized Controlled Trial
Jacques Cosnes,Anne Bourrier,David Laharie,Stéphane Nahon,Yoram Bouhnik,Franck Carbonnel,Matthieu Allez,Jean Louis Dupas,Jean Marie Reimund,Guillaume Savoye,Pauline Jouet,Jacques Moreau,Jean Yves Mary,Jean-Frederic Colombel +13 more
TLDR
Based on results from a clinical trial, administration of azathioprine within 6 months of diagnosis of CD was no more effective than conventional management in increasing time of clinical remission.About:
This article is published in Gastroenterology.The article was published on 2013-10-01. It has received 244 citations till now. The article focuses on the topics: Management of Crohn's disease & Crohn's Disease Activity Index.read more
Citations
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Journal ArticleDOI
Crohn's disease
TL;DR: An physician-oriented overview of Crohn's disease in adults is provided, ranging from epidemiology and cause to clinical diagnosis, natural history, patient stratification and clinical management, and ending with an overview of emerging therapies and future directions for research.
Journal ArticleDOI
Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.
Frank M. Ruemmele,Frank M. Ruemmele,Frank M. Ruemmele,Gábor Veres,Kaija-Leena Kolho,Anne Griffiths,Arie Levine,Johanna C. Escher,J. Amil Dias,Arrigo Barabino,Christian Braegger,Jiri Bronsky,Stephan Buderus,Javier Martín-de-Carpi,L. de Ridder,Ulrika L. Fagerberg,Jean-Pierre Hugot,Jaroslaw Kierkus,Sanja Kolaček,Sibylle Koletzko,Paolo Lionetti,Erasmo Miele,V.M. Navas Lopez,Anders Paerregaard,Richard K Russell,Daniela Elena Serban,Ron Shaoul,P. van Rheenen,Gigi Veereman,B Weiss,David Wilson,Axel Dignass,A Eliakim,Harland S. Winter,Dan Turner +34 more
TL;DR: These guidelines are intended to give practical (whenever possible evidence-based) answers to (pediatric) gastroenterologists who take care of children and adolescents with CD, since many different clinical scenario exist requiring treatment strategies not covered by or different from these guidelines.
Journal ArticleDOI
ACG Clinical Guideline: Management of Crohn’s Disease in Adults
Gary R. Lichtenstein,Edward V. Loftus,Kim L. Isaacs,Miguel Regueiro,Lauren B. Gerson,Bruce E. Sands +5 more
TL;DR: This guideline is intended to be flexible, not necessarily indicating the only acceptable approach, and should be distinguished from standards of care that are inflexible and rarely violated.
Journal ArticleDOI
ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment
Joana Torres,Stefanos Bonovas,Glen A. Doherty,Torsten Kucharzik,Javier P. Gisbert,Tim Raine,Michel Adamina,Michel Adamina,Alessandro Armuzzi,Oliver Bachmann,Palle Bager,Livia Biancone,Bernd Bokemeyer,Peter Bossuyt,Johan Burisch,Paul Collins,Alaa El-Hussuna,Pierre Ellul,Cornelia Frei-Lanter,Federica Furfaro,Christian Gingert,Paolo Gionchetti,Fernando Gomollón,Marien González-Lorenzo,Hannah Gordon,Tibor Hlavaty,Pascal Juillerat,Konstantinos H. Katsanos,Uri Kopylov,Eduards Krustins,Theodore Lytras,Christian Maaser,Fernando Magro,John Marshall,Pär Myrelid,Gianluca Pellino,Isadora Rosa,João Sabino,Edoardo Savarino,Antonino Spinelli,Laurents P. S. Stassen,Mathieu Uzzan,Stephan R. Vavricka,Bram Verstockt,Janindra Warusavitarne,Oded Zmora,Gionata Fiorino +46 more
TL;DR: The present article addresses surgical management, including preoperative aspects and drug management before surgery, and provides technical advice for a variety of common clinical situations.
Journal ArticleDOI
Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease
TL;DR: An updated meta-analysis of randomized controlled trials of oral azathioprine or 6-mercaptopurine compared to placebo or active therapy involving adult patients with quiescent Crohn's disease showed that AZA was significantly superior to placebo for maintenance of remission over a 6 to 18 month period.
References
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Journal ArticleDOI
Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease
Jean-Frederic Colombel,William J. Sandborn,Walter Reinisch,Gerassimos J. Mantzaris,Asher Kornbluth,Daniel Rachmilewitz,Simon Lichtiger,Robert H. Diamond,Delma L. Broussard,Kezhen L. Tang,C. Janneke van der Woude,Paul Rutgeerts +11 more
TL;DR: Patients with moderate-to-severe Crohn's disease who were treated with infliximab plus azathioprine or inflIXimab monotherapy were more likely to have a corticosteroid-free clinical remission than those receiving azATHioprine monotherapy.
Journal ArticleDOI
Long-term evolution of disease behavior of Crohn's disease.
Jacques Cosnes,Stéphane Cattan,Antoine Blain,Laurent Beaugerie,Franck Carbonnel,Rolland Parc,Jean-Pierre Gendre +6 more
TL;DR: Most patients with CD will eventually one day develop a stricturing or a perforating complication, and initial location determines the type of the complication.
Journal ArticleDOI
Estimates of Location Based on Rank Tests
J. L. Hodges,Erich L. Lehmann +1 more
TL;DR: Rank tests such as the two Wilcoxon tests or the Kruskal-Wallis H-test have been shown to be more robust against gross errors than that of the t-and F-tests, even in the rare case in which the suspicion of the possibility of gross errors is unfounded.
Journal ArticleDOI
Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study.
Daniel H. Present,Burton I. Korelitz,Nathaniel Wisch,Joseph L. Glass,David B. Sachar,Bernard S. Pasternack +5 more
TL;DR: 6-MP is an effective and useful agent in the management of Crohn's disease and was more effective than placebo in closing fistulas and in permitting discontinuation or reduction of steroid dosage.
Journal ArticleDOI
Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study
Laurent Beaugerie,Nicole Brousse,Anne Marie Bouvier,Jean-Frederic Colombel,Marc Lémann,Jacques Cosnes,Xavier Hébuterne,Antoine Cortot,Yoram Bouhnik,Jean Pierre Gendre,Tabassome Simon,Marc Maynadié,Olivier Hermine,Jean Faivre,Fabrice Carrat +14 more
TL;DR: Patients receiving thiopurines for inflammatory bowel disease have an increased risk of developing lymphoproliferative disorders, and most cases associated withThiopurine exposure matched the pathological range of post-transplant disease.
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Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial
Geert R. D'Haens,Filip Baert,Gert Van Assche,Philip Caenepeel,Philippe Vergauwe,Hans Tuynman,Martine De Vos,Sander J. H. van Deventer,Larry Stitt,Allan Donner,Allan Donner,Severine Vermeire,Frank J. Van de Mierop,Jean-Charles R Coche,Janneke van der Woude,Thomas Ochsenkühn,Ad A. van Bodegraven,Philippe Van Hootegem,Guy Lambrecht,Fazia Mana,Paul Rutgeerts,Brian G. Feagan,Brian G. Feagan,Daniel W. Hommes +23 more