EBV-positive diffuse large B-cell lymphoma of the elderly
TLDR
This review comprehensively delineates the data emerging from analyses of EBV latency program, microRNA-mediated EBV viral oncogenesis, functional genomics ofEBV and its biology, and differential diagnosis challenge for EBV-positive DLBCL of the elderly.About:
This article is published in Blood.The article was published on 2013-07-18 and is currently open access. It has received 273 citations till now. The article focuses on the topics: Diffuse large B-cell lymphoma & Lymphoma.read more
Citations
More filters
Journal ArticleDOI
EBV-associated T/NK–cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases
Hiroshi Kimura,Yoshinori Ito,Shinji Kawabe,Kensei Gotoh,Yoshiyuki Takahashi,Seiji Kojima,Tomoki Naoe,Shinichi Esaki,Atsushi Kikuta,Akihisa Sawada,Keisei Kawa,Koichi Ohshima,Shigeo Nakamura +12 more
TL;DR: Age at onset of disease and liver dysfunction were risk factors for mortality, whereas patients who received transplantation had a better prognosis, and insight into the diagnostic and therapeutic approaches for distinct disease is provided.
Journal ArticleDOI
Diffuse large B-cell lymphoma.
Maurizio Martelli,Andrés J.M. Ferreri,Claudio Agostinelli,Alice Di Rocco,Michael Pfreundschuh,Stefano Pileri +5 more
TL;DR: In patients with localized DLBCL, available randomized trials suggest that radiation therapy improves local control and disease-free survival and that the addition of radiation therapy cannot replace inadequate chemotherapy.
Journal ArticleDOI
The biology and treatment of plasmablastic lymphoma
TL;DR: The objectives of this review are to summarize the current knowledge on the epidemiology, biology, clinical and pathological characteristics, differential diagnosis, therapy, prognostic factors, outcomes, and potential novel therapeutic approaches in patients with PBL and also to increase the awareness toward PBL in the medical community.
Journal ArticleDOI
Epstein–Barr virus-associated lymphomas
TL;DR: Recent developments in the understanding of EBV-associated lymphomagenesis in both the immunocompetent and Immunocompromised host are reviewed.
Journal ArticleDOI
The Global Landscape of EBV-Associated Tumors.
TL;DR: The main characteristics of these tumors, their distinct epidemiologies, histological features and degrees of EBV association are described, then how their different patterns ofEBV latency may reflect the alternative latency programmes through which the virus first colonizes and then persists in immunocompetent host is considered.
References
More filters
Journal ArticleDOI
Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
Claudio Franceschi,Miriam Capri,Daniela Monti,Sergio Giunta,Fabiola Olivieri,Federica Sevini,Maria Panagiota Panourgia,Laura Invidia,Laura Celani,Maria Scurti,Elisa Cevenini,Gastone Castellani,Stefano Salvioli +12 more
TL;DR: It is proposed that inflammaging can be flanked by anti-inflammaging as major determinants not only of immunosenescence but eventually of global aging and longevity.
Journal ArticleDOI
Radical causes of cancer
TL;DR: Understanding the association between chronic inflammation and cancer provides insights into the molecular mechanisms involved and highlights the interaction between nitric oxide and p53 as a crucial pathway in inflammatory-mediated carcinogenesis.
Journal ArticleDOI
Identification of Virus-Encoded MicroRNAs
Sébastien Pfeffer,Mihaela Zavolan,Friedrich A. Grässer,Minchen Chien,James J. Russo,Jingyue Ju,Bino John,Anton J. Enright,Debora S. Marks,Chris Sander,Thomas Tuschl +10 more
TL;DR: The small RNA profile of cells infected by Epstein-Barr virus is recorded and it is shown that EBV expresses several microRNA (miRNA) genes, which are identified viral regulators of host and/or viral gene expression.
Journal ArticleDOI
Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death.
Sheila Henderson,Martin Rowe,Christopher D. Gregory,Debbie Croom-Carter,Fred Wang,Richard Longnecker,Elliott Kieff,Alan B. Rickinson +7 more
TL;DR: By DNA transfection into human B cells, it is shown that protection from apoptosis is conferred through expression of a single EBV latent protein, the latent membrane protein LMP 1, and it is demonstrated that L MP 1 mediates this effect by up-regulating expression of the cellular oncogene bcl-2.
Journal ArticleDOI
Inositol phosphatase SHIP1 is a primary target of miR-155.
TL;DR: This study unveils a molecular link between miR-155 and SHIP1 and provides evidence that repression ofSHIP1 is an important component of miR -155 biology.
Related Papers (5)
Age-Related EBV-Associated B-Cell Lymphoproliferative Disorders Constitute a Distinct Clinicopathologic Group: A Study of 96 Patients
Takashi Oyama,Kazuhito Yamamoto,Naoko Asano,Aya Oshiro,Ritsuro Suzuki,Yoshitoyo Kagami,Yasuo Morishima,Kengo Takeuchi,Toshiyuki Izumo,Shigeo Mori,Koichi Ohshima,Junji Suzumiya,Naoya Nakamura,Masafumi Abe,Koichi Ichimura,Yumiko Sato,Tadashi Yoshino,Tomoki Naoe,Yoshie Shimoyama,Yoshikazu Kamiya,Tomohiro Kinoshita,Shigeo Nakamura +21 more