Journal ArticleDOI
Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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TLDR
An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.Abstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.read more
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Magnetic immobilization of bacteria using iron oxide nanoparticles
Dinali Ranmadugala,Alireza Ebrahiminezhad,Merilyn Manley-Harris,Younes Ghasemi,Aydin Berenjian +4 more
TL;DR: The potential applications of iron oxide nanoparticles in bacterial cell immobilization will be discussed in this work.
Journal ArticleDOI
Synthesis and physicochemical characterization of mesoporous SiO 2 nanoparticles
Dharani Das,Yong Yang,Julie S. O’Brien,Dalibor Breznan,Surendra Nimesh,Stéphane Bernatchez,Myriam Hill,Abdelhamid Sayari,Renaud Vincent,Prem Kumarathasan +9 more
TL;DR: In this paper, the authors synthesized a library of mesoporous silica nanoparticles with approximate particle sizes of 25, 70, 100, 170, and 600 nm and analyzed their morphology, surface functionality, surface area/pore volume, surface organic content, and dispersion characteristics in liquid media.
Journal ArticleDOI
A spontaneous penetration mechanism of patterned nanoparticles across a biomembrane
Ye Li,Xianren Zhang,Dapeng Cao +2 more
TL;DR: A fundamental understanding is given for the penetration mechanism of the ligand patterned NPs, which provides useful reference for the design of NPs for controllable cell penetrability and targeted delivery of drugs.
Journal ArticleDOI
Dual targeting delivery of miR-328 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy
Yang Li,Yanhong Duo,Peng Zhai,Lisheng He,Keli Zhong,Yue Zhang,Kaibin Huang,Jinfeng Luo,Han Zhang,Xiaofang Yu +9 more
TL;DR: This multifunctional nanoplatform is a promising miRNA replacement therapy for CRC and can achieve an increased binding ability and much higher cytotoxicity to CRC both in vitro and in vivo.
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Morphological and mechanical determinants of cellular uptake of deformable nanoparticles
TL;DR: An elastically deformable NP model with tunable morphological and mechanical properties is built and it is found that the cellular uptake of deformable NPs depends on their shape: an increase in the particle elasticity significantly slows the uptake rate of spherical NPs, slightly retards that of prolate NPs and promotes the uptake of oblate NPs.
References
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
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Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
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Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.