Journal ArticleDOI
Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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TLDR
An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.Abstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.read more
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Facile Peptides Functionalization of Lanthanide-Based Nanocrystals through Phosphorylation Tethering for Efficient in Vivo NIR-to-NIR Bioimaging.
Chi Yao,Peiyuan Wang,Rui Wang,Lei Zhou,Ahmed Mohamed El-Toni,Ahmed Mohamed El-Toni,Yiqing Lu,Xiaomin Li,Fan Zhang +8 more
TL;DR: It is shown that noncovalent surface engineering based on ligand exchange of peptide for lanthanide based upconversion and downconversion near-infrared (NIR) luminescent nanoparticles can be efficiently realized by modifying the hydroxyl functional group of a side grafted serine of peptides into a phosphate group (phosphorylation).
Journal ArticleDOI
On the effect of ligand shell heterogeneity on nanoparticle/protein binding thermodynamics.
TL;DR: An analytical ultracentrifugation (AUC) based method to determine NP/protein binding thermodynamic parameters is used to investigate the binding parameters for a well-defined set of gold NPs with varying size and surface ligand ratios to the model protein human serum albumin and finds that gold NBP with a homogenous distribution of hydrophilic molecules in their ligand shell have a monotonic dependence of their binding constants.
Journal ArticleDOI
Bioactivity of nanosilver in Caenorhabditis elegans: Effects of size, coat, and shape
Piper Reid Hunt,Zachary Keltner,Xiugong Gao,Steven J. Oldenburg,Priyanka Bushana,Nicholas Olejnik,Robert L. Sprando +6 more
TL;DR: The authors' findings in Caenorhabditis elegans correlate well with findings in rodents for AgNP size vs. uptake and toxicity, as well as for induction of immune effectors, while using methods that are faster and far less expensive, supporting the use of C. elegans as an alternative model for early toxicity screening.
Journal ArticleDOI
A review on nanotechnology: Properties, applications, and mechanistic insights of cellular uptake mechanisms
Salman Khan,Shazia Mansoor,Zeeshan Rafi,Bhawna Kumari,Ambreen Shoaib,Mohd Saeed,Sultan Alshehri,Mfohammed M. Ghoneim,Mohamed Rahamathulla,Umme Hani,Faiyaz Shakeel +10 more
TL;DR: The use of nanoparticles in medicine, health, electronics, and the environment has been discussed in this article, where the authors briefly discuss NPs in medication delivery, cancer therapy, protein, and peptide delivery, along with the current understanding of NPs uptake into the mammalian cells and underlying factors governing nano-cellular interactions.
Journal ArticleDOI
Highly efficient intracellular protein delivery by cationic polyethyleneimine-modified gelatin nanoparticles
Ming Ju Chou,Hsing Yi Yu,Jui Ching Hsia,Ying Hou Chen,Tzu Ting Hung,Hsiao Mei Chao,Hsiao Mei Chao,Edward Chern,Yi You Huang +8 more
TL;DR: The PEI-modified gelatin particle may provide a biodegradable and highly efficient protein delivery system for use in regenerative medicine and cancer therapy.
References
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Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Journal ArticleDOI
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.