Journal ArticleDOI
Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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TLDR
An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.Abstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.read more
Citations
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Exploring the role of polymer structure on intracellular nucleic acid delivery via polymeric nanoparticles.
TL;DR: The polymer structural features that enable effective intracellular delivery of DNA and RNA, including protection of nucleic acid cargo, cellular uptake, endosomal escape, vector unpacking, and delivery to the intrACEllular site of activity are discussed.
Journal ArticleDOI
Handling of iron oxide and silver nanoparticles by astrocytes.
TL;DR: The efficient accumulation of large amounts ofMetal-containing NPs and the upregulation of proteins that safely store NP-derived metal ions suggest that astrocytes protect the brain against the potential toxicity of metal- containing NPs.
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Protein Adsorption: A Feasible Method for Nanoparticle Functionalization?
TL;DR: A critical review of adsorption of specific biomolecules onto nanoparticles as one of the methods for natural surface functionalization, and advantages and limitations are highlighted.
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Differential uptake of nanoparticles by human M1 and M2 polarized macrophages: protein corona as a critical determinant
TL;DR: The observed differential uptake by M1 and M2 macrophages will help understand the fate of nanoparticles in vivo and be the ligands for receptors expressed by M2, as revealed by SDS-PAGE and gene profiling analyses.
Journal ArticleDOI
Multifunctional liquid crystal nanoparticles for intracellular fluorescent imaging and drug delivery.
Christopher M. Spillmann,Jawad Naciri,W. Russ Algar,W. Russ Algar,Igor L. Medintz,James B. Delehanty +5 more
TL;DR: A robust multifunctional liquid crystal NP (LCNP)-based delivery system that affords facile intracellular fate tracking coupled with the efficient delivery and modulation of the anticancer therapeutic doxorubicin (Dox), employed here as a model drug cargo.
References
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Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Journal ArticleDOI
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
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Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.