Journal ArticleDOI
Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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TLDR
An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.Abstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.read more
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Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers.
TL;DR: This review will discuss in depth, how modulating the physicochemical properties would influence a drug nanocarrier's behavior in vivo and the mechanisms underlying these effects and provide a conceptual template for achieving improved therapeutic efficacy with enhanced patient compliance.
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Beyond the lipid-bilayer: interaction of polymers and nanoparticles with membranes
TL;DR: The present review assembles investigations on lipid/polymer/nanoparticle interaction with the main focus directed towards model membrane systems published in the recent literature starting from ∼2005, providing a deeper and more thorough understanding of these complex interactions and their effects on membrane properties.
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A systems toxicology approach to the surface functionality control of graphene-cell interactions.
TL;DR: The distinct biological and molecular mechanisms of GO/rGO were attributed to their differential surface oxidation status, and it was displayed that TGFβ1 mediated signaling played the central role in GO induced biological/toxicological effect.
Journal ArticleDOI
Resettable, Multi‐Readout Logic Gates Based on Controllably Reversible Aggregation of Gold Nanoparticles
TL;DR: This work presents a resettable and multi-readout logic system capable of several types of logic operations based on the aggregation of spiropyran-modified gold nanoparticles (SP-AuNPs) in aqueous media and applies this system to construct other kinds of logic gates based on various input signals such as different kinds of metal ions and chelating ligands.
Journal ArticleDOI
Size Dependent Surface Charge Properties of Silica Nanoparticles
TL;DR: In this paper, surface charge properties of silica nanoparticles with different sizes were studied using a multi-ion surface charge-regulation model, where protonation and deprotonation surface reactions were used to obtain the local surface charge, which depends on the particle size and electrolyte solution properties, including salt concentration and pH.
References
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Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
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Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.