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Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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TLDR
An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.Abstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.read more
Citations
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Gold Nanoparticles: Synthesis, Optical Properties, and Application
TL;DR: In this article, the four most frequently used gold nanoparticle species (nanospheres, nanorods, nanoshells, and nanocells) whose surface plasmonic resonance peaks lie in the visible to near-infrared range are considered.
Journal ArticleDOI
The role played by modified bioinspired surfaces in interfacial properties of biomaterials
Thais T. Paterlini,Lucas F. B. Nogueira,Camila B. Tovani,Marcos A.E. Cruz,Rafael Derradi,Ana Paula Ramos +5 more
TL;DR: This review focuses on the creation of particles and modified surfaces inspired by the structure and composition of biogenic mineralized tissues, the development of biofunctional coatings, materials inspired by biomembranes and proteins, and the design of superwettable materials.
Journal ArticleDOI
Advances in studies of nanoparticle-biomembrane interactions.
TL;DR: The aim is to better understand the mechanism of NP-biomembrane interactions and provide significant guidance for various fields, such as nanomedicine and diagnosis.
Journal ArticleDOI
Mitoxantrone-loaded zeolite beta nanoparticles: preparation, physico-chemical characterization and biological evaluation.
TL;DR: This article describes the preparation and the physico-chemical characterization of a new host-guest system consisting of zeolite beta nanoparticles as host and mitoxantrone as guest, which describes the interesting optical properties of guest molecules with a fluorescence emission band in the near-infrared region.
Journal ArticleDOI
Surface chemistry of photoluminescent F8BT conjugated polymer nanoparticles determines protein corona formation and internalization by phagocytic cells.
Raha Ahmad Khanbeigi,Thais Fedatto Abelha,Arcadia Woods,Olivia Rastoin,Richard D. Harvey,Marie-Christine Jones,Ben Forbes,Mark Green,Helen L. Collins,Lea Ann Dailey +9 more
TL;DR: The study results highlight that F8BT surface chemistry influences the composition of the protein corona, while the properties of the conjugated polymer nanoparticle surfactant stabilizer used determine particle internalization and biocompatibility profile.
References
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.