Journal ArticleDOI
Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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TLDR
An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.Abstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.read more
Citations
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Journal ArticleDOI
Soft and Hard Interactions between Polystyrene Nanoplastics and Human Serum Albumin Protein Corona.
Shinji Kihara,Shinji Kihara,Nadine J. van der Heijden,Nadine J. van der Heijden,C. K. Seal,C. K. Seal,Jitendra P. Mata,Andrew E. Whitten,Ingo Köper,Duncan J. McGillivray,Duncan J. McGillivray +10 more
TL;DR: Despite the weak interaction between PS and the HSA corona, small angle neutron scattering revealed the formation of a complex structure that enhanced the intermolecular interactions between HSA proteins, PS particles, and the HS/PSA complexes.
Journal ArticleDOI
Magnetic resonance imaging of the inner ear in Meniere's disease
TL;DR: In animals with immune reaction-induced EH, MRI showed that EH could be limited to restricted regions of the inner ear, and in the same inner ear both EH and leakage of GdC into the scala media were visualized.
Journal ArticleDOI
Nanoparticle-based technologies for retinal gene therapy.
Jeffrey Adijanto,Muna I. Naash +1 more
TL;DR: The primary mechanism of NP uptake by retinal cells is reviewed, various NPs that have been successfully used for in vivo gene delivery to the retina and RPE are highlighted, and the various strategies that can be implemented in the plasmid DNA to generate persistent, high levels of gene expression are considered.
Journal ArticleDOI
Non-Viral Delivery To Enable Genome Editing.
TL;DR: The challenges in the delivery of genome-editing tools are discussed, and recent innovations in non-viral delivery that have potential to overcome these limitations and advance the translation of genome editing towards patient care are highlighted.
Journal ArticleDOI
Membrane Partitioning of Anionic, Ligand-Coated Nanoparticles Is Accompanied by Ligand Snorkeling, Local Disordering, and Cholesterol Depletion
TL;DR: This study proposes a mechanism of cellular anionic NPpartitioning, which requires structural rearrangements of both the NP and the bilayer, and concludes that the translocation of anionic NPs through cholesterol-rich membranes must be accompanied by formation of cholesterol-lean regions in the proximity of NPs.
References
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Journal ArticleDOI
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.