Journal ArticleDOI
Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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TLDR
An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.Abstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.read more
Citations
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Mesoporous silica nanoparticles for therapeutic/diagnostic applications.
Samira Jafari,Hossein Derakhshankhah,Loghman Alaei,Ali Fattahi,Behrang Shiri Varnamkhasti,Ali Akbar Saboury +5 more
TL;DR: The common approaches of cargo loading and release processes from MSNs, the intracellular uptake, safety and cytotoxicity aspects of MSNs are discussed as well.
Journal ArticleDOI
Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy
Xiaodong Zhang,Jie Chen,Zhentao Luo,Di Wu,Xiu Shen,Sha-Sha Song,Yuan-Ming Sun,Pei-Xun Liu,Jing Zhao,Shuaidong Huo,Saijun Fan,Feiyue Fan,Xing-Jie Liang,Jianping Xie +13 more
TL;DR: A new type of metabolizable and efficient radiosensitizers for cancer radiotherapy is presented by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH).
Journal ArticleDOI
Surface Functionalization and Targeting Strategies of Liposomes in Solid Tumor Therapy: A Review.
Muhammad Kashif Riaz,Muhammad Adil Riaz,Xue Zhang,Congcong Lin,Ka Hong Wong,Xiaoyu Chen,Ge Zhang,Aiping Lu,Zhijun Yang +8 more
TL;DR: Information is reviewed about the strategies for targeting of liposomes to solid tumors along with the possible targets in cancer cells, i.e., extracellular and intracellular targets and targets in tumor microenvironment or vasculature.
Journal ArticleDOI
The Interplay of Size and Surface Functionality on the Cellular Uptake of Sub-10 nm Gold Nanoparticles
Ying Jiang,Shuaidong Huo,Shuaidong Huo,Tsukasa Mizuhara,Riddha Das,Yi-Wei Lee,Singyuk Hou,Daniel F. Moyano,Bradley Duncan,Xing-Jie Liang,Vincent M. Rotello +10 more
TL;DR: It is demonstrated that size and surface charge interact in an interrelated fashion to modulate nanoparticle uptake into cells, providing an engineering tool for designing nanomaterials for specific biological applications.
Journal ArticleDOI
The Gold Standard: Gold Nanoparticle Libraries To Understand the Nano–Bio Interface
TL;DR: It is emphasized that the understanding of how nanomaterials will function in a biological system relies on the knowledge of the interface between biological systems and nanommaterials, the nano-bio interface.
References
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Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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Journal ArticleDOI
Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.