Journal ArticleDOI
Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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TLDR
An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.Abstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.read more
Citations
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Voyage inside the cell: Microsystems and nanoengineering for intracellular measurement and manipulation
TL;DR: Improvements in the spatial and temporal resolution of these measurements will provide fresh insight into how the intracellular environment affects the health of cells, the researchers conclude.
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Comparative and mechanistic genotoxicity assessment of nanomaterials via a quantitative toxicogenomics approach across multiple species.
TL;DR: The observation suggested that eukaryotes, especially mammalian cells, are likely more susceptible to genotoxicity than prokaryotes in the ecosystem when exposed to these ENMs, suggesting that the molecular genot toxicity assay is suitable for genotoxic detection.
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Electrostatic interactions favor the binding of positive nanoparticles on cells: A reductive theory
TL;DR: The discovery of a new level of complexity in the interactions with biological systems that cannot be any more limited to electrostatic binding is added: the nanoparticle protein corona.
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Elucidating the endocytosis, intracellular trafficking, and exocytosis of carbon dots in neural cells
Nan Zhou,Shoujun Zhu,Suraj Maharjan,Zeyu Hao,Yubing Song,Xiaohuan Zhao,Yanfang Jiang,Bai Yang,Laijin Lu +8 more
TL;DR: The results suggest that CDs exhibit low cytotoxicity and highly efficient internalization in neural cells.
Journal ArticleDOI
Interaction of nanoplastics with extracellular polymeric substances (EPS) in the aquatic environment: A special reference to eco-corona formation and associated impacts
Muhammad Junaid,Jun Wang +1 more
TL;DR: In this paper, the authors summarized the documented studies highlighting the eco-corona formation on Nanoplastics and associated ecological implications in the aquatic environment and highlighted the potential methods for characterization and quantification of ecocorona and its composition.
References
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Journal ArticleDOI
Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Journal ArticleDOI
Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
Direct gene transfer into mouse muscle in vivo.
Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
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Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.