Journal ArticleDOI
Effect of Surface Properties on Nanoparticle–Cell Interactions
Ayush Verma,Francesco Stellacci +1 more
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TLDR
An understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells is presented.Abstract:
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.read more
Citations
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An Organometallic Strategy for Assembling Atomically Precise Hybrid Nanomaterials
Julia M. Stauber,Elaine A. Qian,Yanxiao Han,Arnold L. Rheingold,Petr Král,Daishi Fujita,Alexander M. Spokoyny +6 more
TL;DR: A bottom-up approach to the systematic assembly of atomically precise hybrid nanoclusters employing a strategy that mimics the synthetic ease with which thiol-capped AuNPs are normally constructed, while producing well-defined covalent nanoscale assemblies with diverse surface topologies is presented.
Journal ArticleDOI
A biophysical perspective of understanding nanoparticles at large
Pu Chun Ke,Monica H. Lamm +1 more
TL;DR: The correlations between the physicochemistry of fullerenes and their uptake, translocation, transformation, transport, and biodistribution in mammalian and plant systems are shown, at the molecular, cellular, and whole organism level.
Journal ArticleDOI
Augmented cellular uptake of nanoparticles using tea catechins: effect of surface modification on nanoparticle–cell interaction
Yi-Ching Lu,Yi-Ching Lu,Pei-Chun Luo,Chun-Wan Huang,Yann-Lii Leu,Tzu-Hao Wang,Kuo-Chen Wei,Hsin-Ell Wang,Yunn-Hwa Ma +8 more
TL;DR: It is demonstrated that EGCG greatly enhanced interaction and/or internalization of MNPs by glioma cells, but not vascular endothelial cells, which reveals a novel interaction of a food component and nanocarrier system which may be potentially amenable to magnetofection, cell labeling/tracing, and targeted therapeutics.
Journal ArticleDOI
A Nano-in-Nano Vector: Merging the Best of Polymeric Nanoparticles and Drug Nanocrystals
Dongfei Liu,Cristina Rodríguez Bernuz,Jin Fan,Wei Li,Alexandra Correia,Jouni Hirvonen,Hélder A. Santos +6 more
TL;DR: The favorable features of both polymer nanoparticles and drug nanocrystals are inherited by the obtained nano‐in‐nano vector, showing ultrahigh drug‐loading degree, biodegradability, pH‐responsive fast dissolution, high stability in serum, and ease of surface functionalization.
Journal ArticleDOI
Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads.
Nadja C. Bigall,Alberto Curcio,Manuel Leal,Andrea Falqui,Domenico Palumberi,Riccardo Di Corato,Ennio Albanesi,Roberto Cingolani,Teresa Pellegrino +8 more
TL;DR: Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method and experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.
References
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Understanding biophysicochemical interactions at the nano–bio interface
Andre E. Nel,Lutz Mädler,Darrell Velegol,Tian Xia,Eric M.V. Hoek,Ponisseril Somasundaran,Fred Klaessig,Vince Castranova,Mike Thompson +8 more
TL;DR: Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
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TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
Journal ArticleDOI
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Jon A. Wolff,Robert W. Malone,Phillip Williams,Wang Chong,Gyula Acsadi,Agnes Jani,Philip L. Felgner +6 more
TL;DR: RNA and DNA expression vectors containing genes for chloramphenicol acetyltransferase, luciferase, and beta-galactosidase were separately injected into mouse skeletal muscle in vivo and expression was comparable to that obtained from fibroblasts transfected in vitro under optimal conditions.
Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.